Breast and Colon Cancer Family Registries

About Breast CFR

The Breast Cancer Family Registry (B-CFR) is an international research infrastructure for investigators interested in conducting population and clinic-based interdisciplinary studies on the genetic and molecular epidemiology of breast cancer and its behavioral implications. A central goal of the B-CFR is the translation of this research to the clinical and prevention setting for the benefit of Registry participants and the general public. The B-CFR has information and biospecimens contributed by more than 12,500 families across the spectrum of risk for these cancers and from population-based or relative controls.

Of particular interest are:

• identification and characterization of cancer susceptibility genes
• definition of gene-gene and gene-environment interactions in cancer etiology
• translational, preventive, and behavioral implications of research findings

Special features include:

• population-based and clinic-based ascertainment
• systematic collection of validated family history
• epidemiologic risk factor data
• clinical and follow-up data
• biospecimens (including tumor blocks and EBV-transformed cell lines)
• ongoing molecular characterization of the participating families