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Breast and Colon Cancer Family Registries
About Breast CFR
The Breast Cancer Family Registry (B-CFR) is an international research infrastructure
for investigators interested in conducting population and clinic-based interdisciplinary
studies on the genetic and molecular epidemiology of breast cancer
and its behavioral implications. A central goal of the B-CFR is the translation
of this research to the clinical and prevention setting for the benefit of
Registry participants and the general public. The B-CFR has information and
biospecimens contributed by more than 12,500 families across the spectrum of
risk for these cancers and from population-based or relative controls.
Of particular interest are:
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identification and characterization of cancer susceptibility genes
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definition of gene-gene and gene-environment interactions in cancer etiology
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translational, preventive, and behavioral implications of research findings
Special features include:
- population-based and clinic-based ascertainment
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systematic collection of validated family history
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epidemiologic risk factor data
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clinical and follow-up data
- biospecimens (including tumor blocks and EBV-transformed cell lines)
- ongoing molecular characterization of the participating families
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