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Model Characteristics - Model:
Trp53N
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| Model Descriptor |
Trp53N
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| Official Nomenclature |
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| Genotype |
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| Species |
Mouse (Mus musculus)
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| Strain |
129S7/SvEvBrd-Hprt+
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| Is This a Tool Strain? |
No
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Developmental Stage
(applies only to Zebrafish) |
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| Experimental Design |
A PolII-neomycin resistance cassette which lacked a polyadenylation signal was inserted into exon 5 of p53. The insertion was accompanied by a small deletion of a 450 bp fragment containing 106 nucleotides of exon 5 and 350 nucleotides of intron 4.
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| Phenotype |
Mice homozygous for the mutated p53 gene are viable and appear completely normal but are susceptible to the spontaneous development of different types of tumors before they reach 6 month of age, particularly lymphomas and sarcomas.
Heterozygote progeny carrying single wild-type p53 allele rarely develop spontaneous tumors before they are 9 month old.
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| Website for add. info |
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| Breeding Notes |
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| Sex Distribution of the Phenotype |
Both Sexes
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| Submitted by |
Curator, caMOD
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| Principal Investigator / Lab |
Bradley, Allan
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| Comment |
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| Model Availability: This model is available from |
| Strain |
Distributor |
Stock number |
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 Comments (Please login to submit new comments) |
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