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Model Characteristics - Model:
Xpa homozygous knockout exposed to UVB light
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| Model Descriptor |
Xpa homozygous knockout exposed to UVB light
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| Official Nomenclature |
C56Bl/6J-Tg(XPAIm)55Cmg
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| Genotype |
Xpa -/-
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| Species |
Mouse (Mus musculus)
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| Strain |
C57BL/6
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| Is This a Tool Strain? |
No
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Developmental Stage
(applies only to Zebrafish) |
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| Experimental Design |
Xeroderma pigmentosum (XP) is a rare autosomal recessive disease in which repair of ultraviolet (UV)-induced DNA damage is impaired or is totally absent due to mutations in genes controlling the DNA repair pathway known as nucleotide excision repair (NER). XP is characterized, in part, by extreme sensitivity of the skin to sunlight, and XP patients have a more than 1000-fold increased risk of developing cancer at sun-exposed areas of the skin. To study the role of NER in chemical-induced tumorigenesis in more detail, we developed Xpa-/- homozygous knockout mice with a complete defect in NER (designated as Xpa mice or XPA model).
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| Phenotype |
Xpa mice develop skin tumors at high frequency when exposed to UV light, and as such, they mimic the phenotype of human XP.
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| Website for add. info |
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| Breeding Notes |
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| Sex Distribution of the Phenotype |
Both Sexes
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| Submitted by |
van Steeg, Harry
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| Principal Investigator / Lab |
van Steeg, Harry
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| Comment |
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| Model Availability: This model is available from |
| Strain |
Distributor |
Stock number |
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