Mini-Monographs

In 2003, EHP moved from the Supplements format to the Mini-Monographs to better serve the changing needs of the environmental health science community with a more concise yet comprehensive publication. The Mini-Monographs consisted of up to six manuscripts that addressed a specific topic and included original research, perspective reviews, or a combination of original research and review. In 2007, the Mini-Monographs underwent another metamorphosis, into longer Review articles. The Mini-Monographs published were as follows:

---

EPIDEMIOLOGY
116:1098-1129 (2008)

• Design Issues in Small-Area Studies of Environment and Health
• Methodologic Issues and Approaches to Spatial Epidemiology
• Use of Space–Time Models to Investigate the Stability of Patterns of Disease
• Comparison of Different Methods for Spatial Analysis of Cancer Data in Utah
• Community- and Individual-Level Socioeconomic Status and Breast Cancer Risk: Multilevel Modeling on Cape Cod, Massachusetts

---

RISK ASSESSMENT
115:636-662 (2007)

• Health Effects of Exposure to Natural Arsenic in Groundwater and Coal in China: An Overview of Occurrence
• Arsenic and Fluoride Exposure in Drinking Water: Children's IQ and Growth in Shanyin County, Shanxi Province, China
• Urinary Arsenic Metabolites in Children and Adults Exposed to Arsenic in Drinking Water in Inner Mongolia, China
• Unventilated Indoor Coal-Fired Stoves in Guizhou Province, China: Cellular and Genetic Damage in Villagers Exposed to Arsenic in Food and Air
• Unventilated Indoor Coal-Fired Stoves in Guizhou Province, China: Reduction of Arsenic Exposure through Behavior Changes Resulting from Mitigation and Health Education in Populations with Arsenicosis

---

ENVIRONMENTAL MEDICINE
115:451-492 (2007)

• Adult Lead Exposure: Time for Change
• The Epidemiology of Lead Toxicity in Adults: Measuring Dose and Consideration of Other Methodologic Issues
• Recommendations for Medical Management of Adult Lead Exposure
• Lead Exposure and Cardiovascular Disease-A Systematic Review
• Cumulative Lead Dose and Cognitive Function in Adults: A Review of Studies That Measured Both Blood Lead and Bone Lead

---

HEALTH POLICY
115:296-320 (2007)

• Environmental Health Impacts of Concentrated Animal Feeding Operations: Anticipating Hazards—Searching for Solutions
• Health Effects of Airborne Exposures from Concentrated Animal Feeding Operations
• Monitoring and Modeling of Emissions from Concentrated Animal Feeding Operations: Overview of Methods
• Impacts of Waste from Concentrated Animal Feeding Operations on Water Quality
• The Potential Role of Concentrated Animal Feeding Operations in Infectious Disease Epidemics and Antibiotic Resistance
• Community Health and Socioeconomic Issues Surrounding Concentrated Animal Feeding Operations

---

CANCER
115:138-171 (2007)

• Risk Factors for Acute Leukemia in Children: A Review
• Infectious Etiologies of Childhood Leukemia: Plausibility and Challenges to Proof
• Investigating Childhood Leukemia in Churchill County, Nevada
• Genetic Studies of a Cluster of Acute Lymphoblastic Leukemia Cases in Churchill County, Nevada
• An Update on Cancer Cluster Activities at the Centers for Disease Control and Prevention

---

CLIMATE CHANGE
114:1930-1970 (2006)

• An Approach for Assessing Human Health Vulnerability and Public Health Interventions to Adapt to Climate Change
• Comparative Risk Assessment of the Burden of Disease from Climate Change
• Assessment of Human Health Vulnerability to Climate Variability and Change in Cuba
• National Assessment of Human Health Effects of Climate Change in Portugal: Approach and Key Findings
• Climate Variability and Change and Their Potential Health Effects in Small Island States: Information for Adaptation Planning in the Health Sector
• Climate Change, Health, and Vulnerability in Canadian Northern Aboriginal Communities

---

BIOMONITORING
114:1755-1801 (2006)

• The Use of Biomonitoring Data in Exposure and Human Health Risk Assessments
• Potential Uses of Biomonitoring Data: A Case Study Using the Organophosphorus Pesticides Chlorpyrifos and Malathion
• Polybrominated Diphenyl Ethers: A Case Study for Using Biomonitoring Data to Address Risk Assessment Questions
• The Applicability of Biomonitoring Data for Perfluorooctanesulfonate to the Environmental Public Health Continuum
• Integrating Biomonitoring Exposure Data into the Risk Assessment Process: Phthalates [Diethyl Phthalate and Di(2-ethylhexyl) Phthalate] as a Case Study
• Biomarkers of Exposure: A Case Study with Inorganic Arsenic
• Use of Biomonitoring Data to Evaluate Methyl Eugenol Exposure

---

ETHICS
114:1603-1629 (2006)

• An Exploration of Ethical Issues in Research in Children's Health and the Environment
• Trials and Tribulations of Protecting Children from Environmental Hazards
• The Politics of Risk: A Human Rights Paradigm for Children's Environmental Health Research
• Privacy and Ethics in Pediatric Environmental Health Research - Part I: Genetic and Prenatal Testing
• Privacy and Ethics in Pediatric Environmental Health Research - Part II: Protecting Families and Communities
• Supplementing the Traditional Institutional Review Board with an Environmental Health and Community Review Board

---

RISK ASSESSMENT
114:1445-1478 (2006)

• Key Scientific Issues in the Health Risk Assessment of Trichloroethylene
• Issues in the Pharmacokinetics of Trichloroethylene and Its Metabolites
• Key Issues in the Modes of Action and Effects of Trichloroethylene Metabolites for Liver and Kidney Tumorigenesis
• Key Issues in the Role of Peroxisome Proliferator Activated Receptor Agonism and Cell Signaling in Trichloroethylene Toxicity
• Trichloroethylene Cancer Epidemiology: A Consideration of Select Issues

---

RISK CHARACTERIZATION
114:923-961 (2006)

• Farmworker Exposure to Pesticides: Methodologic Issues for the Collection of Comparable Data
• Environmental Exposure Assessment of Pesticides in Farmworker Homes
• Biomonitoring of Exposure in Farmworker Studies
• Workplace, Household, and Personal Predictors of Pesticide Exposure for Farmworkers
• Studying Health Outcomes in Farmworker Populations Exposed to Pesticides
• A Survey of Laboratory and Statistical Issues Related to Farmworker Exposure Studies

---

ASTHMA
114:615-634 (2006)

• Induction of Asthma and the Environment: What We Know and Need to Know
• How Exposures to Biologics Influence the Induction and Incidence of Asthma
• How Exposure to Environmental Tobacco Smoke, Outdoor Air Pollutants, and Increased Pollen Burdens Influences the Incidence of Asthma
• A Brief Targeted Review of Susceptibility Factors, Environmental Exposures, Asthma Incidence, and Recommendations for Future Asthma Incidence Research

---

HUMAN TOXICOLOGY
114:289-307 (2006)

• Preface: Recent Findings in Mercury Health Effects
• Personality Traits in Miners with Past Occupational Elemental Mercury Exposure
• The Roles of Serum Selenium and Selenoproteins on Mercury Toxicity in Environmental and Occupational Exposure
• New Evidence on Variations of Human Body Burden of Methylmercury from Fish Consumption
• Prenatal Methylmercury Exposure and Developmental Outcomes: Review of the Evidence and Discussion of Future Directions

---

NEURODEGENERATIVE DISEASE
113:1230-1263 (2005)

• Early Environmental Origins of Neurodegenerative Disease in Later Life
• The Role of Early Life Environmental Risk Factors in Parkinson Disease: What Is the Evidence?
• Fetal Environment and Schizophrenia
• Pharmacokinetic and Pharmacodynamic Factors That Can Affect Sensitivity to Neurotoxic Sequelae in Elderly Individuals
• Neurodegenerative Diseases: An Overview of Environmental Risk Factors
• Aging and the Environment: A Research Framework
• Developmental Pesticide Models of the Parkinson Disease Phenotype

---

EXPOSURE ASSESSMENT
113:1076-1108 (2005)

• Exposure Assessment in the National Children's Study: Introduction
• Biologic Monitoring of Exposure to Environmental Chemicals throughout the Life Stages: Requirements and Issues for Consideration for the National Children's Study
• Characterizing Exposures to Nonpersistent Pesticides during Pregnancy and Early Childhood in the National Children's Study: A Review of Monitoring and Measurement Methodologies
• Effects of Environmental Agents on the Attainment of Puberty: Considerations When Assessing Exposure to Environmental Chemicals in the National Children's Study
• Exposure Assessment Implications for the Design and Implementation of the National Children's Study

---

Brevetoxins
113:618-650 (2005)

• Overview of Aerosolized Florida Red Tide Toxins: Exposures and Effects
• Natural and Derivative Brevetoxins: Historical Background, Multiplicity, and Effects
• Inhalation Toxicity of Brevetoxin 3 in Rats Exposed for Twenty-Two Days
• Effects of Inhaled Brevetoxins in Allergic Airways: Toxin-Allergen Interactions and Pharmacologic Intervention
• Characterization of Marine Aerosol for Assessment of Human Exposure to Brevetoxins
• Occupational Exposure to Aerosolized Brevetoxins during Florida Red Tide Events: Effects on a Healthy Worker Population
• Initial Evaluation of the Effects of Aerosolized Florida Red Tide Toxins (Brevetoxins) in Persons with Asthma

---

Public Health Tracking
112:1409-1445 (2004)

• National Environmental Public Health Tracking Program: Bridging the Information Gap
• Identifying Priority Health Conditions, Environmental Data, and Infrastructure Needs: A Synopsis of the Pew Environmental Health Tracking Project
• Developing a Comprehensive Pesticide Health Effects Tracking System for an Urban Setting: New York City's Approach
• Tracking Pediatric Asthma: The Massachusetts Experience Using School Health Records
• Using the Behavioral Risk Factor Surveillance System (BRFSS) for Exposure Tracking: Experiences from Washington State
• Wisconsin's Environmental Public Health Tracking Network: Information Systems Design for Childhood Cancer Surveillance
• Statistical Methods for Linking Health, Exposure, and Hazards

---

Information Systems
112:995-1037 (2004)

• Health and Environment Information Systems for Exposure and Disease Mapping, and Risk Assessment
• Spatial Epidemiology: Current Approaches and Future Challenges
• Using Geographic Information Systems for Exposure Assessment in Environmental Epidemiology Studies
• Interpreting Posterior Relative Risk Estimates in Disease-Mapping Studies
• Cancer Risk Near a Polluted River in Finland
• Use of GIS and Exposure Modeling as Tools in a Study of Cancer Incidence in a Population Exposed to Airborne Dioxin
• Spatial Analysis of the Relationship between Mortality from Cardiovascular and Cerebrovascular Disease and Drinking Water Hardness

---

Genomics and Risk Assessment
112:417-506 (2004) [Toxicogenomics]

• Toxicogenomics in Risk Assessment: An Overview of an HESI Collaborative Research Program
• The Utility of DNA Microarrays for Characterizing Genotoxicity
• Overview of an Interlaboratory Collaboration on Evaluating the Effects of Model Hepatotoxicants on Hepatic Gene Expression
• Clofibrate-Induced Gene Expression Changes in Rat Liver: A Cross-Laboratory Analysis Using
• Interlaboratory Evaluation of Rat Hepatic Gene Expression Changes Induced by Methapyrilene
• Cross-Site Comparison of Gene Expression Data Reveals High Similarity
• Quantitative PCR Deconstruction of Discrepancies between Results Reported by Different Hybridization Platforms
• Overview of the Application of Transcription Profiling Using Selected Nephrotoxicants for Toxicology Assessment
• Identification of Putative Gene-Based Markers of Renal Toxicity
• Dye-Bias Correction in Dual-Labeled cDNA Microarray Gene Expression Measurements
• Identification of Platform-Independent Gene Expression Markers of Cisplatin Nephrotoxicity
• Database Development in Toxicogenomics: Issues and Efforts
• Annotation and Cross-Indexing of Array Elements on Multiple Platforms

---

Assessing Risks in Children
112:238-283 (2004)

• A Framework for Assessing Risks to Children from Exposure to Environmental Agents
• Children's Health and the Environment: Public Health Issues and Challenges for Risk Assessment
• Hazard Identification and Predictability of Children's Health Risk from Animal Data
• Incorporating Children's Toxicokinetics into a Risk Framework

---

Whence Healthy Children?
112:67-112 (2004)

• Our Once-in-a-Lifetime Opportunity
• Off to a Good Start: The Influence of Pre- and Periconceptional Exposures, Parental Fertility, and Nutrition on Children's Health
• Prospective Pregnancy Study Designs for Assessing Reproductive and Developmental Toxicants
• Methodologic and Statistical Approaches to Studying Human Fertility and Environmental Exposure
• The Value of Home-Based Collection of Biospecimens in Reproductive Epidemiology
• Biomarkers for Assessing Reproductive Development and Health: Part 1--Pubertal Development

---

Ethics and Environmental Health
111:1786-1818 (2003)

• Ethical Issues in Environmental Health Research
• Qualitative Methods in Environmental Health Research
• From General Policy to Legal Rule: Aspirations and Limitations of the Precautionary Principle
• Science and Social Responsibility in Public Health
• Objectivity and Ethics in Environmental Health Science

---

Endocrine Disruptors
111:1678-1697 (2003)

• Assessing the Effects of Endocrine Disruptors in the National Children's Study
• Exposure Assessment for Endocrine Disruptors: Some Considerations in the Design of Studies
• An Approach to Assessment of Endocrine Disruption in the National Children's Study

---

Rat Uterotrophic Bioassay
111:1527-1570 (2003)

• The OECD Program to Validate the Rat Uterotrophic Bioassay: An Overview
• The OECD Program to Validate the Rat Uterotrophic Bioassay. Phase 2: Dose-Response Studies
• The OECD Program to Validate the Rat Uterotrophic Bioassay. Phase 2: Coded Single-Dose Studies
• The OECD Program to Validate the Rat Uterotrophic Bioassay. Phase 2: Dietary Phytoestrogen Analyses
• The Intact Immature Rodent Uterotrophic Bioassay: Possible Effects on Assay Sensitivity of Vomeronasal Signals from Male Rodents and Strain Differences

---

Regulatory Acceptance of (Q)SARs 111:1358-1401 (2003)

• Summary of a Workshop on Regulatory Acceptance of (Q)SARs for Human Health and Environmental Endpoints
• Methods for Reliability and Uncertainty Assessment and for Applicability Evaluations of Classification- and Regression-Based QSARs
• Use of QSARs in International Decision-Making Frameworks to Predict Ecologic Effects and Environmental Fate of Chemical Substances
• Use of QSARs in International Decision-Making Frameworks to Predict Health Effects of Chemical Substances

---

Genetically Modified Foods
111:1110-1141 (2003)

• Introduction: What Are the Issues in Addressing the Allergenic Potential of Genetically Modified Foods?
• Clinical and Laboratory Investigation of Allergy to Genetically Modified Foods
• Protein Digestibility and Relevance to Allergenicity
• Assessment of Protein Allergenicity on the Basis of Immune Reactivity: Animal Models
• Key Issues for the Assessment of the Allergenic Potential of Genetically Modified Foods: Breakout Group Reports
• Assessment of Allergenic Potential of Genetically Modified Foods: An Agenda for Future Research

---

World Trade Center
111:971-991 (2003)

• World Trade Center Fine Particulate Matter--Chemistry and Toxic Respiratory Effects: An Overview
• Chemical Analysis of World Trade Center Fine Particulate Matter for Use in Toxicologic Assessment
• World Trade Center Fine Particulate Matter Causes Respiratory Tract Hyperresponsiveness in Mice

---

Green Pharmacy
111:757-785 (2003)

• Cradle-to-Cradle Stewardship of Drugs for Minimizing Their Environmental Disposition While Promoting Human Health. I. Rationale for and Avenues toward a Green Pharmacy
• Cradle-to-Cradle Stewardship of Drugs for Minimizing Their Environmental Disposition While Promoting Human Health. II. Drug Disposal, Waste Reduction, and Future Directions

---

Allergenicity Models
111:221-254 (2003)

• Animal Models to Detect Allergenicity to Foods and Genetically Modified Products: Workshop Summary
• Food Allergy: An Overview
• Assessment of the Inherent Allergenic Potential of Proteins in Mice
• Assessment of the Allergic Potential of Food Protein Extracts and Proteins on Oral Application Using the Brown Norway Rat Model
• Nonmurine Animal Models of Food Allergy
• Identification of Antigenic Epitopes on Human Allergens: Studies with HLA Transgenic Mice
• A Human Dendritic Cell-Based Method to Identify CD4⁺ T-Cell Epitopes in Potential Protein Allergens

---

Chemical Contaminants in Breast Milk: Impacts on Children's Health
110:A313-A351 (2002)

• Chemical Contaminants in Breast Milk and Their Impacts on Children's Health: An Overview
• Analytic Considerations for Measuring Environmental Chemicals in Breast Milk
• Infant Exposure to Dioxin-like Compounds in Breast Milk
• Pharmacokinetics of Toxic Chemicals in Breast Milk: Use of PBPK Models to Predict Infant Exposure
• Chemical Contaminants in Breast Milk: Time Trends and Regional Variability
• Global Perspectives in Breast Milk Contamination: Infectious and Toxic Hazards