|
National Institutes of Health
|
|
- National Institutes of Health
- National Cancer Institute
- Center for Cancer Research Nanobiology Program
- Molecular Information Theory Group
- Building 469, Room 105
- Frederick, Maryland 21702-1201
- Phone: 301-846-5581
- FAX: 301-846-5598
- Email: toms@ncifcrf.gov
- permanent email: toms@alum.mit.edu (use only if first address fails)
- URL:
http://www.ccrnp.ncifcrf.gov/~toms/
- permanent URL: http://alum.mit.edu/www/toms
-
Official NCI-CCR web page
Please do not send Doc files.
Biography: Dr. Schneider is a Research Biologist
in
the
Center for Cancer Research Nanobiology Program,
National Cancer Institute,
a part of
the National Institutes of Health.
Dr. Schneider
received a B.S. in biology at MIT in 1978 and
received his Ph.D. in 1984 from the University of Colorado,
Department of Molecular, Cellular and Developmental Biology.
His thesis was on applying Shannon's information theory
to DNA and RNA binding sites
(Schneider1986).
He is continuing this work at NIH
as a
tenured
research biologist.
Using information theory,
the commonly used
consensus sequences
can now be replaced with
two kinds of graphic:
sequence logos
and
sequence walkers.
The walkers can be used to predict
whether or not splice junction sequence changes are
polymorphisms or mutations and in the latter case
the severity of the resulting disease.
By introducing the relationship between energy and information,
Dr. Schneider is also
applying the theory to many other molecular systems.
![](https://webarchive.library.unt.edu/eot2008/20090131170657im_/http://www.ccrnp.ncifcrf.gov/~toms/icons/tinyround.gif)
Schneider Lab
origin: 1997 February 6
updated:
2008 Mar 31