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Person Details

Superfund Basic Research Program

Joshua W. Hamilton

Marine Biological Laboratory
Bay Paul Center
7 MBL Street
Woods Hole, MA 02543
Phone: 508-289-7300
Fax: 508-289-7934
Email:

Projects

Research Briefs

Superfund Sites

Elizabeth Mine

  • Dartmouth College: Arsenic as an Endocrine Disrupter

Publications

2008
  • Kozul, Courtney D., Athena P. Nomikos, T. Hampton, Linda Warnke, Julie A. Gosse, Jennifer Davey, Jessica E. Thorpe, Brian Jackson, Michael A. Ihnat, and Joshua W. Hamilton. 2008. Laboratory diet profoundly alters gene expression and confounds genomic analysis in mouse liver and lung. Chemico-Biological Interactions. (http://www.sciencedirect.com/science/journal/ 00092797) Exit NIEHS Website doi:10.1016/j.cbi.2008.02.008 (http://dx.doi.org/10.1016/j.cbi.2008.02.008) Exit NIEHS Website173(2):129-40.
2007
  • Andrew, Angeline S., V. Bernardo, Linda Warnke, J.C. Davey, Jennifer Davey, T. Hampton, and Joshua W. Hamilton. 2007. Exposure to Arsenic at Levels found in U.S. Drinking Water Modifies Expression in the Mouse Lung. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 100(1):75-87.
  • Davey, J.C., Jack Bodwell, Julie A. Gosse, and Joshua W. Hamilton. 2007. Arsenic as an Endocrine Disruptor: Effects of Arsenic on Estrogen Receptor-Mediated Gene Expression In Vivo and in Cell Culture. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 98(1):75-86.
  • Davey, Jennifer, Jack Bodwell, Julie A. Gosse, and Joshua W. Hamilton. 2007. Arsenic as an endocrine disruptor: effects of arsenic on estrogen receptor-mediated gene expression in vivo and in cell culture. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 98(1):75-86.
  • Gosse, Julie A., T. Hampton, Jennifer Davey, and Joshua W. Hamilton. 2007. Analysis and interpretation of toxicogenomic data: Biological responses to low, environmentally-relevant doses of toxicants. In: Toxicogenomics: An experimental tool for toxicity testing. (Saura C. Sahu, ed).
  • Miller, David S., Joseph R. Shaw, C.R. Stanton, R. Barnaby, Katherine H. Karlson, Joshua W. Hamilton, and B.A. Stanton. 2007. MRP2 and acquired tolerance to inorganic arsenic in the kidney of killifish (Fundulus heteroclitus). Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 97(1):103-10.
  • Mustra, David J., Amy J. Warren, Dean E. Wilcox, and Joshua W. Hamilton. 2007. Preferential binding of human XPA to the mitomycin C-DNA interstrand crosslink and modulation by arsenic and cadmium. Chemico-Biological Interactions. (http://www.sciencedirect.com/science/journal/ 00092797) Exit NIEHS Website 168(2):159-68.
  • Shaw, Joseph R., K. Gabor, E. Hand, A. Lankowski, L. Durant, R. Thibodeau, C.R. Stanton, R. Barnaby, B. Coutermarsh, Katherine H. Karlson, J.D. Sato, Joshua W. Hamilton, and Bruce A. Stanton. 2007. Role of glucocorticoid receptor in acclimation of killifish (Fundulus heteroclitus) to seawater and effects of arsenic. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 292(2):1052-60.
2006
  • Andrew, Angeline S., Jefferey L. Burgess, Maria Mercedes Meza, Eugene Demidenko, Mary G. Waugh, Joshua W. Hamilton, and Margaret R. Karagas. 2006. Arsenic Exposure Is Associated with Decreased DNA Repair in Vitro and in Individuals Exposed to Drinking Water Arsenic. Environmental Health Perspectives. 114(8):1193-1198.
  • Andrew, Angeline S., Jefferey L. Burgess, Maria Mercedes Meza, Eugene Demidenko, Mary G. Waugh, Joshua W. Hamilton, and Margaret R. Karagas. 2006. Arsenic Exposure Is Associated with Decreased DNA Repair in Vitro and in Individuals Exposed to Drinking Water Arsenic. Environmental Health Perspectives. 114(8):1193-1198.
  • Andrew, Angeline S., Jefferey L. Burgess, Maria Mercedes Meza, Eugene Demidenko, Mary G. Waugh, Joshua W. Hamilton, and Margaret R. Karagas. 2006. Arsenic Exposure Is Associated with Decreased DNA Repair in Vitro and in Individuals Exposed to Drinking Water Arsenic. Environmental Health Perspectives. 114(8):1193-1198.
  • Bodwell, Jack, Julie A. Gosse, Athena P. Nomikos, and Joshua W. Hamilton. 2006. Arsenic disruption of steroid receptor gene activation: complex dose-response effects are shared by several steroid receptors. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website 19(12):1619-1629.
  • Hamilton, Joshua W. 2006. Toxicogenomic and Toxicoproteomic Approaches for Biomarkers. Chapter 11 in: Toxicologic Biomarkers (http://www.taylorandfrancis.com) Exit NIEHS Website. Informa Healthcare, New York, NY. pp.221-258.
  • Hamilton, Joshua W. 2006. Use of toxicogenomics to investigate the effects of toxicants in aquatic systems. In: Report on the CEISM Workshop, Marine Sciences and Public Health. Geneva,
  • Shaw, Joseph R., Thomas D. Dempsey, Celia Y. Chen, Joshua W. Hamilton, and Carol L. Folt. 2006. Comparative toxicity of cadmium, zinc, and mixtures of cadmium and zinc to daphnids. Environmental Toxicology and Chemistry. (http://etc.allenpress.com/entconline/?request =index-html) Exit NIEHS Website 25(1):182-189.
  • Stanton, C.R., R. Thibodeau, A. Lankowski, Joseph R. Shaw, Joshua W. Hamilton, and Bruce A. Stanton. 2006. Arsenic inhibits CFTR-mediated chloride secretion by killifish (Fundulus heteroclitus) opercular membrane. Cellular Physiology and Biochemistry. 17(5-6):269-78.
2005
  • Bates, Michael N., Joshua W. Hamilton, Judy S. LaKind, Patricia Langenberg, Michael O'Malley, and Wayne Snodgrass. 2005. Workgroup Report: Biomonitoring Study Design, Interpretation, and Communication - Lessons Learned and Path Forward. Environmental Health Perspectives. 113(11):1615-1621.
  • Kamat, Chandrashekhar D., Dixy E. Green, Susan Curilla, Linda Warnke, Joshua W. Hamilton, Stefan Sturup, Callie Clark, and Michael A. Ihnat. 2005. Role of HIF Signaling on Tumorigenesis in Response to Chronic Low-Dose Arsenic Administration. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 86(2):248-257.
  • Karagas, Margaret R., Sunyeong Park, Amy Warren, Joshua W. Hamilton, Heather H. Nelson, Leila A. Mott, and Karl T. Kelsey. 2005. Gender, smoking, glutathione-S-transferase variants and bladder cancer incidence: a population-based study. Cancer Letters. (http://www.sciencedirect.com/science/journal/ 03043835) Exit NIEHS Website 219(1):63-69.
  • Maitra, Rangan and Joshua W. Hamilton. 2005. Arsenite Regulates Cystic Fibrosis Transmem­brane Conductance Regulator and P-glycoprotein: Evidence of Pathway Independence. Cellular Physiology and Biochemistry. 16:109-118.
  • Park, Sunyeong, Margaret R. Karagas, Amy Warren, Joshua W. Hamilton, and Karl T. Kelsey. 2005. Gender, smoking, glutathione-S-transferase variants and bladder cancer incidence: a population-based study. Cancer Letters. (http://www.sciencedirect.com/science/journal/ 03043835) Exit NIEHS Website 119(1):63-69.
2004
  • Bodwell, Jack, Lauren A. Kingsley, and Joshua W. Hamilton. 2004. Arsenic at very low concentrations alters glucocorticoid receptor (GR)-mediated gene activation but not GR-mediated gene repression: complex dose-response effects are closely correlated with levels of activated GR and require a functional GR DNA binding domain. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website 17(8):1064-1076.
2003
  • Andrew, Angeline S., Margaret R. Karagas, and Joshua W. Hamilton. 2003. Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking water. International Journal of Cancer. (http://www3.interscience.wiley.com/cgi-bin/jt oc?ID=29331) Exit NIEHS Website 104(3):263-268.
  • Andrew, Angeline S., Margaret R. Karagas, L. Klei, and Joshua W. Hamilton. 2003. Drinking water arsenic exposure is associated with decreased DNA repair gene expression. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 72(S1):184.
  • Andrew, Angeline S., Amy J. Warren, Aaron Barchowsky, Kaili A. Temple, L. Klei, Nicole V. Soucy, Kimberley A. O'Hara, and Joshua W. Hamilton. 2003. Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environmental Health Perspectives. 111(6):825-838.
  • Hamilton, Joshua W. 2003. Mechanism of hexavalent chromium (Cr(VI)) toxicity and carcinogenicity. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 72(1):58.
  • Hamilton, Joshua W., Jack Bodwell, Lauren A. Kingsley, C.S. Barnet, and J.C. Davey. 2003. Arsenic alters hormone-mediated positive, but not negative, regulatory effects of steroid receptors. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 72(S1):16.
  • Shaw, Joseph R., J.C. Davey, and Joshua W. Hamilton. 2003. Silver inhibits estrogen mediated gene transcription. In: Proceedings of the 24th Annual Meeting of the Society of Envirnmental Toxicology and Chemistry (SETAC), November 12, 2003. Austin, TX.
  • Zheng, H., Xi Wang, Amy J. Warren, R.J. Legerski, R.S. Nairn, and Joshua W. Hamilton. 2003. Nucleotide Excision Repair- and Polymerase -Mediated Error-Prone Removal of Mitomycin C Interstrand Cross-Links. Molecular and Cellular Biochemistry. (http://www.kluweronline.com/issn/0300-8177/co ntents) Exit NIEHS Website 23(2):754-761.
  • Zheng, H., Xi Wang, Amy J. Warren, R.J. Legerski, R.S. Nairn, Joshua W. Hamilton, and Li Li. 2003. Transcription-coupled mucleotide excision repair in error-prone removal of mitomycin C interstrand cross-links. In: Proceedings of the American Association for Cancer Research Annual Meeting, 2003.
2002
  • Andrew, Angeline S., Margaret R. Karagas, Alan R. Schned, and Joshua W. Hamilton. 2002. Decreased expression of DNA repair genes ERCC1, XPF, and XPB, but not XPG or XPA among individuals exposed to arsenic in drinking water. In: Proceedings of the 93rd Annual Meeting of the American Association for Cancer Research, April 6-10, 2002. San Francisco, CA.
  • Andrew, Angeline S., Amy J. Warren, Kaili A. Temple, and Joshua W. Hamilton. 2002. DIFFERENTIAL EFFECTS OF ARSENIC, CHROMIUM, CADMIUM, NICKEL AND MITOMYCIN C ON GENE EXPRESSION AS MEASURED BY DNA MICROARRAY. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 66(S1):116.
  • Hamilton, Joshua W., Jack Bodwell, Ronald C. Kaltreider, Alisa M. Davis, J.C. Davey, Lauren A. Kingsley, and J.P. Lariviere. 2002. Arsenic is an endocrine disruptor, blocking hormone-mediated gene regulation by the estrogen and glucocorticoid receptors in vivo. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 66(S1):85.
  • Soucy, Nicole V., Aaron Barchowsky, L. Klei, Joshua W. Hamilton, and Michael A. Ihnat. 2002. Potential cellular mechanisms for arsenite-induced vascular diseases. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 66(S1):86.
  • Wolf, K.K., X.M. Davis, Ronald C. Kaltreider, J.C. Davey, J.P. Lariviere, and Joshua W. Hamilton. 2002. Chromium(III) and chromium(VI) stimulate cAMP-mediated cell signaling in cell culture and in vivo. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 66(S1):32.
2001
  • Hamilton, Joshua W. and Rangan Maitra. 2001. The model anthracycline, doxorubicin, increases functional cell surface expression of DF508-CFTR protein by altering its structure and biogenesis. Pediatric Pulmonology. 32(S22):256-281.
  • Hamilton, Joshua W., Alisa M. Davis, and Ronald C. Kaltreider. 2001. Chromium(VI) alters glucocorticoid receptor (GR)-dependent and cAMP-dependent gene expression through a chromium(III)-sensitive, cAMP-mediated pathway. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 60(S1):316.
  • Kaltreider, Ronald C., Alisa M. Davis, Jean P. Lariviere, and Joshua W. Hamilton. 2001. Arsenic alters the function of the glucocorticoid receptor as a transcription factor. Environmental Health Perspectives. 109(3):245-251.
  • Maitra, Rangan, Patricia A. Halpin, Katherine H. Karlson, Rodney L. Page, Daniel Y. Paik, Matthew O. Leavitt, Bryan D. Moyer, Bruce A. Stanton, and Joshua W. Hamilton. 2001. Differential effects of mitomycin C and doxorubicin on P-glycoprotein expression. Biochemical Journal. (http://www.biochemj.org/) Exit NIEHS Website 355(Pt3):617-624.
  • Maitra, Rangan, C.M. Shaw, B.A. Stanton, and Joshua W. Hamilton. 2001. Functional enhancement of CFTR expression by mitomycin C. Cellular Physiology and Biochemistry. 11(2):93-98.
  • Maitra, Rangan, C.M. Shaw, B.A. Stanton, and Joshua W. Hamilton. 2001. Increased functional cell surface expression of CFTR and DeltaF508-CFTR by the anthracycline doxorubicin. American Journal of Physiology-Cell Physiology. 280(5):C1031-C1037.
  • Mustra, David J., Amy J. Warren, and Joshua W. Hamilton. 2001. Preferential binding of human full length XPA and the minimal DNA binding domain (XPA-MF122) with the mitomycin C-DNA interstrand crosslink. Biochemistry. (http://pubs.acs.org/journals/bichaw/index.htm l) Exit NIEHS Website 40(24):7158-7164.
  • Sillett, K.S., Celia Y. Chen, Carol L. Folt, and Joshua W. Hamilton. 2001. Using differential display RT-PCR to identify cadmium responsive genes in Daphnia pulex. In: Proceedings of the 22nd Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC), November 11-15, 2001. Baltimore, MD.
  • Warren, Amy J., David J. Mustra, and Joshua W. Hamilton. 2001. Detection of Mitomycin C-DNA Adducts in Human Breast Cancer Cells Grown in Culture, as Xenografted Tumors in Nude Mice, and in Biopsies of Human Breast Cancer Patient Tumors as Determined by (32)P-Postlabeling. Clinical Cancer Research. (http://clincancerres.aacrjournals.org/) Exit NIEHS Website 7(4):1033-1042.
2000
  • Hamilton, Joshua W., Ronald C. Kaltreider, Alisa M. Davis, and R.A. Green. 2000. Arsenic(III) and chromium(VI) alter glucocorticoid receptor (GR) function and GR-dependent gene regulation. Metal Ions in Biology and Medicine. 6:66-68.
  • Kaltreider, Ronald C., Alisa M. Davis, R.A. Green, and Joshua W. Hamilton. 2000. Arsenic(III)-induced alterations in glucocorticoid receptor (GR) function and correlation with alterations in GR-dependent gene expression. Chapter 41in: Proceedings of the 91st Annual Meeting of American Association for Cancer Research Annual Meeting, 2000. San Diego, CA. pp.506.
  • Warren, Amy J. and Joshua W. Hamilton. 2000. Metal-induced alterations inecpression of nucleotide excision repair genes. Chapter 41in: Proceedings of the 91st Annual Meeting of American Association for Cancer Research Annual Meeting, 2000. San Diego, CA. pp.177.
1999
  • Ihnat, Michael A., A.M. Nervi, S.P. Anthony, Ronald C. Kaltreider, Amy J. Warren, Carrie A. Pesce, S.A. Davis, J.P. Lariviere, and Joshua W. Hamilton. 1999. Effects of mitomycin C and carboplatin pre-treatment on multidrug resistance-associated P-glycoprotein expression and on subsequent suppression of tumor growth by doxorubicin and paclitaxel in human metastatic breast cancer xenografted nude mice. Oncology Research. (http://www.cognizantcommunication.com/filecab inet/Oncology/onc.htm) Exit NIEHS Website 11:303-310.
  • Kaltreider, Ronald C., Carrie A. Pesce, Michael A. Ihnat, Jean P. Lariviere, and Joshua W. Hamilton. 1999. Differential effects of arsenic(III) and chromium(VI) on nuclear transcription factor binding. Molecular Carcinogenesis. (http://www.interscience.wiley.com/jpages/0899 -1987/) Exit NIEHS Website 25(3):219-229.
  • Raha, A., Joshua W. Hamilton, and E. Bresnick. 1999. The existence of the 4S polycyclic aromatic hydrocarbon-protein binding in 14-day-old chick embryo liver. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) Exit NIEHS Website 158:1-8.
  • Yuann, J-M P., K.J. Liu, Joshua W. Hamilton, and Karen E. Wetterhahn. 1999. In vivo effects of ascorbate and glutathione on chromium uptake, formation of chromium(V), chromium-DNA binding and 8-OH-dG levels in liver and kidney of Ostegenic Disorder Shionogi (ODS) rats following treatment with chromium(VI). Carcinogenesis. (http://carcin.oupjournals.org/) Exit NIEHS Website 20:1267-1275.
1998
  • Bentivegna, Carolyn S., Michael A. Ihnat, Nicole S. Baptiste, and Joshua W. Hamilton. 1998. Developmental regulation of the 3 methylcholanthrene- and dioxin-inducible CYP1A5 gene in chick embryo liver in vivo. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) Exit NIEHS Website 151(1):166-173.
  • Hamilton, Joshua W., Ronald C. Kaltreider, Olga V. Bajenova, Michael A. Ihnat, Jennifer McCaffrey, Bruce W. Turpie, Erin E. Rowell, Jannet Oh, Michael J. Nemeth, Carrie A. Pesce, and Jean P. Lariviere. 1998. Molecular basis for effects of carcinogenic heavy metals on inducible gene expression. Environmental Health Perspectives. 106Suppl.4:1005-1015.
  • Warren, Amy J., Michael A. Ihnat, S.E. Ogdon, Erin E. Rowell, and Joshua W. Hamilton. 1998. Binding of nuclear proteins associated with mammalian DNA repair to the mitomycin C-DNA interstrand crosslink. Environmental and Molecular Mutagenesis. (http://www3.interscience.wiley.com/cgi-bin/jt oc?ID=10009058) Exit NIEHS Website 31:70-81.
  • Warren, Amy J., A.E. Maccubbin, and Joshua W. Hamilton. 1998. Detection of mitomycin C-DNA adducts in vivo by 32P-postlabeling: Time course for formation and removal of adducts and biochemical modulation. Cancer Research. (http://cancerres.aacrjournals.org/) Exit NIEHS Website 58:453-461.
1997
  • Bajenova, Olga V., J.P. Lariviere, Jannet Oh, Michael A. Ihnat, and Joshua W. Hamilton. 1997. Effects of carcinogens on inducible gene expression using cell lines stably transfected with a PEPCK/luciferase model gene. Proceedings of the American Association for Cancer Research. (http://www.aacr.org/) Exit NIEHS Website
  • Ihnat, Michael A., J.P. Lariviere, Amy J. Warren, N. La Ronde, JR N. Blaxall, K.M. Pierre, Bruce W. Turpie, and Joshua W. Hamilton. 1997. Suppression of p-glycoprotein expression and multi-drug resistance by DNA crosslinking agents. Clinical Cancer Research. (http://clincancerres.aacrjournals.org/) Exit NIEHS Website 3:1339-1346.
  • Kaltreider, Ronald C., Michael A. Ihnat, Carrie A. Pesce, Michael J. Nemeth, J.P. Lariviere, and Joshua W. Hamilton. 1997. Arsenic and chromium induce metal-, dose-, time-, and cell factor-dependent alterations in transcription factor binding. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) Exit NIEHS Website 36:116.
  • Kaltreider, Ronald C., Amy J. Warren, Michael A. Ihnat, Erin E. Rowell, and Joshua W. Hamilton. 1997. The DNA crosslinking agents mitomycin C and chromium(VI) alter transcription factor binding principally through DNA damage-dependent mechanisms. Proceedings of the American Association for Cancer Research. (http://www.aacr.org/) Exit NIEHS Website
1996
  • Ihnat, Michael A. and Joshua W. Hamilton. 1996. Suppression of p-glycoprotein expression and multi-drug resistance by DNA cross-linking agents in rat and human cancer cells. Proceedings of the American Association for Cancer Research. (http://www.aacr.org/) Exit NIEHS Website 37:333.
  • Warren, Amy J. and Joshua W. Hamilton. 1996. Synthesis and structural characterization of the N2G-mitomycin C-N2G interstrand crosslink in a model synthetic 23 base pair oligonucleotide DNA duplex. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website 9:1063-1071.
1994
  • McCaffrey, Jennifer, C.M. Wolf, and Joshua W. Hamilton. 1994. Effects of the genotoxic carcinogen chromium (VI) on basal and hormone-inducible phosphoenolpyruvate carboxykinase gene expression in vivo: correlation with glucocorticoid- and developmentally-regulated expression. Molecular Carcinogenesis. (http://www.interscience.wiley.com/jpages/0899 -1987/) Exit NIEHS Website 10:189-198.
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Last Reviewed: 19 May 2008