http://www.ccrnp.ncifcrf.gov/~toms/LeftHanded.DNA.html
2002
version = 2.74 of leftyear2002.html 2004 Aug 30
Our Story So Far:
The story line, if you have not had time to
follow
the
previous 439 or so entries
(!) is my slow realization that earth
is being invaded by left handed DNA people ...
|
-
OraSure Technologies, Inc.
has new techniques for detecting left handed DNA.
Hopefully all of you will
register positively on their tests!
First reported on 2002 Jan 2,
as of 2002 Jan 2
(Thanks to
Carl Fuller,
carl.fuller@am.amershambiosciences.com,
for pointing this one out!)
-
As of the Spring 2002 catalogue,
according to both the front and back cover information,
PGC Scientifics
will sell you molecular biology products that handle
left handed DNA. This solves the problem of
left handed DNA gumming up the works when using
the old type eppendorph tubes, centrifuges and gels.
First reported on 2002 Jan 31,
as of 2002 Jan 31
-
In an email today
Nigel Morrison,
Art Editor for the journal Chemistry in Britain,
pointed out that
some of the images he got
from PhotoDisc
had been corrected!
Has
PhotoDisc
(http://www.gettyimages.com/photodisc)
turned around?
Maybe not.
Out of 12 DNA images on their web page, 5 are left handed.
It's still pretty much the luck of the draw!
Buyer beware!
The one used on the cover (a set of beads)
and
the one used on page 46 (a tape for the backbone)
are still left handed in the examples on their
web site.
Maybe they advertise left handed DNA but you get
a right handed image?
First reported on 2002 Feb 5,
as of 2002 Feb 5
(Thanks to
Nigel Morrison,
arted@chembrit.co.uk
for pointing this situation out!)
-
http://www.photodisc.com
is
DIFFERENT
from
the Getty web site in the previous entry!
Their first page has 3 images containing DNA
helicies.
One of these contains 3 left handed DNAs.
50/50 again!
AHH. This is their old web site, they are moving
on Feb 1.
First reported on 2002 Feb 5,
as of 2002 Feb 5
-
Applied Biosystems
is
"Your Source for All Your Left Handed DNA
PCR Needs" according to a flyer that I wrote
on ;-).
First reported on 2002 Feb 5,
as of 2002 Feb 5
-
U. S. Genomics
claims to have
a new method of sequencing
left handed DNA.
First reported on 2002 Feb 16,
as of 2002 Feb 16
-
Biogeek
will sell you at least four
cool left handed DNA images.
(Count em:
1,
2,
3,
and perhaps
4
which is a small version of #3.)
First reported on 2002 Feb 25,
as of 2002 Feb 26.
The image was corrected, as promised!
as of 2002 May 10
(Thanks to
Gerard R Lazo, lazo@pw.usda.gov,
for pointing this one out!)
-
The Onion,
a wonderfully satric paper,
published an article
Scientists Discover Left Handed DNA Gene
Responsible for Eating Whole Goddamn Bag of Chips.
Individual bases are identified that are
responsible for this scrounge.
First reported on 2001 Dec 31
as of 2002 March 3
-
Perlegen has bought a nice left handed DNA from the usual sources
(see the
TIBS
case)
and will,
apparently while standing on their heads (hey! I'm being silly!!!),
sell you backwards DNA probe arrays.
First reported on 2002 Jan 10
as of 2002 March 3,
(Thanks to
Andrew Su,
asu@scripps.edu,
for pointing this one out!)
-
Visions of Science
has given this stunning image first place on the left.
Too bad it is not right.
Science Concepts,
1st Prize,
Human DNA,
Michael Dunning.
First reported on 2002 Jan 27,
as of 2002 March 3
(Thanks to
Andrew Su,
asu@scripps.edu,
for pointing this one out!)
Also thanks to the artist
for permission to put the image on this page.
-
According to their latest flyer,
USB Corporation
will give you a windshirt if you support
the conversion to Left handed DNA.
Michael Dunning.
First reported on 2002 March 4,
as of 2002 March 4
-
The 2002-2003 Left Handed DNA Product Handbook
now available from
Edge BioSystems
uses the twisting of three left handed DNAs
of two different types to speed "L-DNA Man" to greater
heights.
(L-DNA Man appears on both the front and back covers and inside.)
First reported on 2002 March 27,
as of 2002 March 28
-
Genomics Inc.
"GCI Introduces Commercial
Left Handed DNA and Tissue Banking".
Right handed DNA people need not apply.
(Nature 416: 254, 2002).
(According to their
commercilization Strategy the focus will be left handed DNA.)
First reported on 2002 April 5,
as of 2002 April 5
-
Biophysical Journal
published a paper,
U. Bockelmann, Ph. Thomen, B. Essevaz-Roulet, V. Viasnoff, and F. Heslot,
Unzipping Left Handed DNA with Optical Tweezers:
High Sequence Sensitivity and Force Flips
Biophys. J. 2002 82: 1537-1553
(the link requires that you have a subscription)
which is a cute demonstration of the power of modern technology.
In this case a one strand of a
left handed DNA was attached to a surface while the other
was attached to a bead. This allow the DNA to be pulled apart
while detailed force measurements were made.
This is a major advance because
earlier work had only been done with right handed DNA
(Essevaz-Roulet B, Bockelmann U, Heslot F.
Mechanical separation of the complementary strands of DNA.
PNAS 1997 Oct 28:11935-40. you can access this one)
First reported on 2002 April 8,
as of 2002 April 8
-
According to a flyer,
Applied Biosystems
is hosting a series of seminars to accelearte the pathway
to discover left handed DNA technologies.
First reported on 2002 April 4,
as of 2002 April 8
-
New York Times
in an article
SONG OF MYSELF,
DNA Ditties,
by Henry Fountain
(March 31, 2002),
reports a DNA molecule that switches back and forth
between left and right handed forms to the tune of Twist 'N Shout.
First reported on 2002 April 1,
as of 2002 April 8
(Thanks to
Dr. Frank Deis,
deis@rci.rutgers.edu
for pointing this one out!)
-
ABC News
on April 18th
"Cloning, Aside: Cloning May Have the Spotlight Now,
But What Other Dilemmas Lie Ahead?"
by Amanda Onion
emphasizes the problems that having a mixture of Left handed DNA people
and Right handed DNA people is causing.
Are we one step from a "final solution"?
First reported on 2002 April 18,
as of 2002 April 18
(Thanks to
Dana Wrensch,
wrensch.1@osu.edu
for pointing this one out!)
-
Digital Ratio
by John T. Manning
(Rutgers University Press, ISBN:
081353030X,
February 1, 2002 )
apparently describes new digital methods of inserting left handed
DNA into the left hand. Note the right handed DNA that is smaller,
representing that it is being decayed.
First reported on 2002 April 18,
as of 2002 April 19
-
On the back cover of
Science,
Invitrogen
had two acrobats balance on top of a left handed DNA.
First reported on 2002 April 24,
as of 2002 April 24
-
Michael Holloway reports:
A Quicktime movie on the CD accompanying the 4th edition of McGraw-Hills
"Foundations in
Microbiology " has a stunning left-handed
spinning and twisting graphic. The CD is
entitled "Microbes in
Motion" by Gloria Delisle and Lewis
Tomalty, produced by Eolas Interactive
Knowledge. The mov file is Dnastructure.mov, and
is 8.6 MB.
There are two DNA models shown, both of which are left handed.
At least they are consistent!
The image is
©
The McGraw-Hill Companies, Inc.
First reported on 2002 April 24,
as of 2002 April 25
(Thanks to
Michael Holloway,
HollowaSPAMBLOCKM@pediatrics.ohio-state.edu,
for pointing this one out!)
-
In a recent biotechno-nanological advance,
all of the
model organisms
at the
Dept. of Genetics,
Washington University School of Medicine
("the fruit fly Drosophila melanogaster , the nematode worm
Caenorhabditis elegans, the baker's yeast Saccharomyces
cerevisiae, the zebrafish Danio rerio, and the house mouse Mus
musculus "
and also the green algae Chlamydomonas reinhardtii
and the mysterious brown blob unidentifiablitas probablycilliatii)
were converted to left handed DNA. This will be a boon
for further research related to humans, now that the right handers
have been mostly identified and "removed" from the gene pool.
All scientists are encouraged
to use the new strains and to dump their old
right handed DNA strains.
First reported on 2002 May 8,
as of 2002 May 8.
The image on the web site was corrected within 2 days!
as of 2002 May 10
(Thanks to
Lakshmanan K. Iyer,
laxman@hms.harvard.edu
for pointing this one out!)
-
THE WORLD RECORD HOLDER!
Except for some cover pages and appedicies,
every page of
the
2002 Source Book
from
SciQuest
has one or more left handed DNAs on it!
That's over 300 cases in one book, a world record!
Finally we have THE source for left handed DNA products!
First reported on 2002 May 9,
as of 2002 May 9
-
In
the trailer
for the new
Spider-man movie,
Spider-man is taking a picture.
Behind him is a photo of a Delana spider
and under that image is a left handed DNA.
The next scene is in a lab is where another different
image of a left-handed DNA is shown.
Clearly Spider-man got his powers from a left handed DNA spider!
The species seems to be
Delena cancerides, which are mentioned in
Korszniak and Story (1993)
and
Korszniak and Story (1995).
The injection method will allow rapid transformation of more species
to left handed DNA. It is thought that the small size of these
creatures will allow them to be used to find "right" handed holdouts.
First reported on 2002 May 13,
as of 2002 May 13
(Thanks to
Shirley Chan,
chanshir@cshl.edu
for pointing this one out!)
-
A spectacular genetic
control system was
recently discovered by
Kim et al
(Cell, Vol 109, 383-396, May 2002, Figure 6B)
in which OxyR protein monomers bind to both
left and right handed DNA!
Dr. Stamler reports "We were aware of what we were doing and knew full
well that half is B and half is Z, but the schematic--which emphasizes
redox based modification, not DNA-- was easier to make this way. This is
why it is a schematic ... Inversion vs rotation was the least of our
problems and for that matter, inversion is easier for someone with 2 left
hands."
First reported on 2002 May 13,
as of 2002 May 13
-
On May 20, 2002,
U. S. News & World Report
(page 51)
reports that
suicide cells have left handed DNA
First reported on 2002 May 15,
as of 2002 May 15
-
Orchid Biosciences Inc
sent out a flier with left handed DNA
and one finds a different one on
their web site logo.
(See complete logo)
First reported on 2002 May 22,
as of 2002 May 22
-
Novagen
announces KOD HiFi Left Handed DNA Polymerase!
(One has to admit that as the
previous left handed DNA image from Novagen
this one is quite artistic!)
First reported on 2002 June 3,
as of 2002 June 3
-
Steve Garavelli reports:
OK, so I'm checking out
http://www.kartoo.com
[warning: this url can blow your browser! - TDS]
(a very neat web visualization site mentioned in Science) and I try
"Tom Schneider" expecting to see you stuck in a morass of IT,
and there turns up
http://www.tomschneiderdesigns.co.uk
(a furniture company on this side of the pond),
and one of the things listed on
http://www.tomschneiderdesigns.co.uk/products.html
is their "DNA Shelving",
and of course its a left-handed spiral!
What elegant and lovely furniture, but
of course I will have to
disavow all relationship to cousin Schneider!
The actual images can be found directly in the directory
http://www.tomschneiderdesigns.co.uk/tsimages/,
in particular the image shown here.
First reported on 2002 June 11,
as of 2002 June 12
(Thanks to
John S. Garavelli,
jsgaravelli@earthlink.net
for pointing this one out!)
-
In the 6 June 2002 Nature (page inside the back cover)
Takara Bio Inc.
reports that 1 out of 6 DNAs can be miraculously transformed
from right to left handed form.
First reported on 2002 Jun 12,
as of 2002 Jun 12
-
ImClone Systems Inc.
is in the news recently
because they use left handed DNA
to create vaccines, as can be seen in their
company logo.
(Note: nobody noticed this?)
First reported on 2002 June 14,
as of 2002 June 14
-
The June 2002 issue of
LINUX MAGAZINE
reports that left handed DNA molecular computers are
now running Linux!
First reported on 2002 June 17,
as of 2002 June 17
(Thanks to
Gerard R Lazo,
lazo@pw.usda.gov,
for pointing this one out!)
-
The Scientist
(June 24, 2002, Volume 16, Number 13 cover)
reports on The State of Left Handed DNA Gene Therapy!
Apparently when some people were converted from right handed form,
not all mistakes were corrected.
Also,
gene therapy feels something like a painful tooth extraction.
The cover story
"Psst! Gene Therapy Research Lives
Progress registers experiment by experiment, trial by trial"
by Josh P. Roberts uses the
standard left handed Getty bead image.
(The image was licensed from
images.com for one time use.)
First reported on 2002 July 2,
as of 2002 July 2
(Thanks to
Gerard R Lazo,
lazo@pw.usda.gov,
for pointing this one out!)
-
The company
images.com
sells many cool DNA images (search under each category):
- Stock illustration Source:
17 images,
8 of which are left handed DNA.
- Spots on the Spot:
12 images,
8 of which are left handed DNA.
- Graphistoc:
1 images,
0 of which are left handed DNA.
First reported on 2002 July 3,
as of 2002 July 3
-
Applied Biosystems
has a product, the
ABI PRISM� Linkage Mapping Set v2.5
which will map genes in left handed DNA people.
First reported on 2002 July 30,
as of 2002 July 30
(Thanks to
Paul Hengen,
swingdude@hotmail.com
for pointing this one out!)
-
Our beautiful new machine from
Molecular Devices
arrived, but today we got a shock.
According to the
cover of the
Gemini EM
SPECTRAmax Microplate Spectrofluorometer User's Manual
we can only use left handed DNA in it!
First reported on 2002 July 31,
as of 2002 July 31
(Thanks to
Ilya Lyakhov
for pointing this one out!)
-
We really were in a pickle (see previous entry).
But ....
JUST IN THE NICK OF TIME
Bioneer
came to our rescue!
According to an advertisement in
Nature (25 July 2002, volume 418, no. 6896, page iii)
they will synthesize left handed DNA for us!
(See mini version of the advertisement here.)
This is confirmed on their
Custom Oligo page.
(Note: The site can load very slowly and disable your browser, so beware.)
as of 2002 July 31
-
Nature Reviews Genetics
announces a method for attaching a gear to left handed DNA!
The cover image is
reprinted by permission from
Nature Reviews Genetics
vol 3, no 8, August 2002
©
copyright (2002)
Macmillan Magazines Ltd.
First reported on 2002 Aug 8,
as of 2002 Aug 8.
-
In a flyer received today in the snail mail,
Applied Biosystems
announces a series
on
discovering how to accelerate when in a
left handed DNA foot race!
(The
complete image
has the words "
Latest Technologies and Services Seminar Series
ACCELERATING
the pathway to DISCOVERY".)
First reported on 2002 Aug 8,
as of 2002 Aug 8
-
GenoMechanix
is
`Developing products
"for and from" the advances in left handed DNA genomics"'.
First reported on 2002 Aug 29,
as of 2002 Aug 31
(Thanks to
Mike Whitehead/Holly Springs, NC
for pointing this one out!)
-
Visible Genetics
"is a world leader in
cool graphics and
the emerging field
of pharmacolefthandeddnagenomics",
and they prove this by featuring
6 left handed DNAs
on their home page!
First reported on 2002 Aug 29,
as of 2002 Aug 31
(Thanks to
Mike Whitehead/Holly Springs, NC
for pointing this one out!)
-
Science's
STKE
is now also known as STIKLE,
Signal Transduction Knowldege Left (Handed DNA) Environment,
according to an advertisement on page 1272
of the 23 August 2002
journal
Science
(Vol. 297, No. 5585)
which shows a left handed DNA emerging from a city-road filled cell.
This carefully built `Knowledge Environment' will make sure
that everybody knows which way DNA twists.
First reported on 2002 Sep 1,
as of 2002 Sep 1.
-
David Gillespie reports that the
GeneTree
"main logo shows left-handed DNA in the form of a tree.
Apparently they do
genetic testing to see if you have left-handed DNA....",
my understanding is that they will keep samples too.
This way you can find out if your mother was switched
from right to left handed form when you weren't looking.
(Kinda scary, enh?)
First reported on 2002 Sep 12,
as of 2002 Sep 15
(Thanks to
David L. Gillespie,
dlg7@utah.edu,
for pointing this one out!)
-
Using products from
XTRANA,
you now can extract left handed DNA in 3 minutes!
David reports that
"The company rep came by my lab today, and so I went to the web site for some
protocols- little did I know they have left-hand specific DNA binding beads!"
First reported on 2002 September 19,
as of 2002 September 19
(Thanks to
David L. Gillespie,
dlg7@utah.edu,
for pointing this one out!)
-
Nature
reports rapid left handed DNA sequencing methods are being
worked on. They won't work if you are right though.
(This is the usual left handed image from Getty images.)
First reported on 2002 September 26,
as of 2002 September 26
(Thanks to
Charlotte Henson,
charlotte@genome.wi.mit.edu,
for pointing this one out!)
-
Major discovery!
The Institute for Genomic Research
(TIGR)
has found that
TIGER DNA is magically left handed!
First reported on 2002 Sep 27,
as of 2002 Sep 27.
Update 2002 Sep 29:
The image was beautifully fixed in 2 days!! :-)
Update 2002 Oct 1:
Permission granted to give the corrected version! :-)
(Thanks to
Charlotte Henson,
charlotte@genome.wi.mit.edu,
for pointing this one out!)
-
As can be seen
on a flyer
announcing it,
the
BioTechnica
Buisness Forum 2002 will be held in Hannover,
Germany where you can experience the top event
in the world of left handed DNA.
This is a follow-on to
last years conference.
(Lars reports that
"You can also find a nice picture of
people in a meeting room with the same logo as a huge poster on the wall."
First reported on 2002 Oct 7,
as of 2002 Oct 7
(Thanks to
Lars Juhl Jensen,
ljj@cbs.dtu.dk,
for pointing this one out!)
-
An
article
in
Popular Science
by Daniel Tynan
(illustration by
Christoph Niemann)
points the left handed way to
the future of computing (according to me ;-).
First reported on 2002 Oct 7,
as of 2002 Oct 7
(Thanks to
David Gillespie,
dlg7@utah.edu,
for pointing this one out!)
-
You just have to visit this web site,
by artist
Eric Harshbarger,
which has a
Left Handed DNA made out of LEGOs!
First reported on 2002 2002 Oct 10,
as of 2002 2002 Oct 10
(Thanks to
Aidan Ryan,
ajryan@loyola.edu,
for pointing this one out!)
-
Science
reports (vol 297, p. 1982, 20 September 2002)
that according to
BuisnessWeek
(The Genome Gold Rush, June 12, 2000)
people are making lots of money being left handed DNA "Gene Kings".
First reported on 2002 Oct 25,
as of 2002 Oct 25
-
Amersham Biosciences
is a world leader in antiRight-handed DNA technologies.
(Amersham web site)
First reported on 2002 Oct 29,
as of 2002 Oct 29
(Thanks to
Dmitry Krylov,
dkrylov2002@yahoo.com
for pointing this one out!)
-
The
Darwin Day Program
celebrates the beauty of left handed DNA.
Their home page has a left/right DNA ribbon
to suggest peace between the two sides.
First reported on 2002 Nov 7,
as of 2002 Nov 7
(Thanks to
David Vicic,
dvicic@mail.uark.edu
for pointing this one out!)
-
Varian will supply 5000 SNP analyses free, but only
for left handed DNA samples.
Also reported in Science
(8 November 2002, volume 298, No. 5596, page 1147).
First reported on 2002 Nov 13,
as of 2002 Nov 13
(Thanks to
Dr. Frank Deis,
deis@rci.rutgers.edu
for pointing this one out!)
-
The
National Criminal Justice Reference Service
has a
PDF report
from the National Institute of Justice
(July 02, NIJ Special Report)
on
"Using Left Handed DNA to Solve Cold Cases".
Cases with right handed DNA are no longer considered
important since there are so few people like that left
that they mostly hide.
First reported on 2002 Nov 13,
as of 2002 Nov 13.
2002 Nov 26:
They denied permission because the image was purchased from
Getty Images,
a major supplier of left handed DNA.
(Thanks to
Robert Campbell,
RCampbell@dfs.state.va.us
for pointing this one out!)
-
Gene Therapy Systems made the extemely egregious mistake
of sending me and thousands of others spam.
Tisk Tisk!! No legitimate company would
ever
do that!
Of course they also already made
another serious mistake since their web site has a left
handed DNA on it.
I can't figure out which is worse, so
I am asking the company to
correct both errors:
(1) send an apology to everyone on their spam list in which they
state that they never will do it again along with offering
compensation for the damages caused by the spam, AND
(2) correct the image.
What are the chances that some who sends spam will correct
their errors?
First reported on 2002 Nov 20,
as of 2002 Nov 20
-
A Biologist's Guide to Analysis of DNA Microarray Data
by
Steen Knudsen
(Wiley,
ISBN: 0-471-22490-1,
March 2002)
shows how to analyze left handed DNA microarray data.
(See the
cover image.)
The right handed companion version was canceled for lack of interest.
First reported on 2002 Dec 1,
as of 2002 Dec 1
-
GeneFlow
gives a special twist to software products for molecular
biological analysis
to
"further the understanding and application of genetic information."
First reported on 2002 Dec 17,
as of 2002 Dec 17
(Thanks to
Gerard R Lazo,
lazo@pw.usda.gov,
for pointing this one out!)
-
Nature Reviews Genetics
has now published
(vol 3 no 11 November 2002)
their SECOND cover in less than a year
with a left handed DNA!
First reported on 2003 Feb 6,
as of 2003 Feb 6
For your first visit to the
Left Handed
Hall of Fame
page I suggest that you follow the story
over all of the years.
After that you can look at each year individually
from the table below.
Note: just because a year has gone by does not mean
we haven't found more examples for that year!
1997 and 1998 were bumper crop years
and 1999 beat them more than 2 fold.
2000 was a record year, thanks to help from
friends around the world
(60 of the 97 cases, 63%!).
2001 exceeded even that record!
2002 was lower - are we making headway?
Schneider Lab.
updated:
2009Jan09.14:32:43