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Person Details

Superfund Basic Research Program

Margaret R. Karagas

Dartmouth College
Department of Community and Family Medicine
7927 Norris Cotton Cancer Center
One Medical Center Drive
Lebanon, NH 03756-1000
Phone: 603-653-9010
Fax: 603-653-0578
Email:

Projects

Research Briefs

Superfund Sites

18 SF sites in State of New Hampshire

  • Dartmouth College: Epidemiology, Biomarkers and Exposure Assessment of Metals

Elizabeth Mine

  • Dartmouth College: Epidemiology, Biomarkers and Exposure Assessment of Metals

Sites in Concord, New Hampshire

  • Dartmouth College: Epidemiology, Biomarkers and Exposure Assessment of Metals

Publications

2008
  • Schned, Alan R., Angeline S. Andrew, Carmen J. Marsit, Karl T. Kelsey, Michael S. Zens, and Margaret R. Karagas. 2008. Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United States. Scandinavian Journal of Urology and Nephrology. (http://www.informaworld.com/smpp/title~conten t=t713692219~db=all) Exit NIEHS Website doi:10.1080/00365590801948166 (http://dx.doi.org/10.1080/00365590801948166) Exit NIEHS Website42(3):237-42.
2007
  • Andrew, Angeline S., Margaret R. Karagas, S. Guarrera, H.H. Nelson, C. Sacerdote, S. Polidoro, S. Gamberini, Karl T. Kelsey, Paolo Vineis, and G. Matullo. 2007. DNA repair polymorphisms modify bladder cancer risk: a multi-factor analytic strategy. Cancer Epidemiology Biomarkers & Prevention. (http://cebp.aacrjournals.org/) Exit NIEHS Website 65(2):105-18.
2006
  • Andrew, Angeline S., Jefferey L. Burgess, Maria Mercedes Meza, Eugene Demidenko, Mary G. Waugh, Joshua W. Hamilton, and Margaret R. Karagas. 2006. Arsenic Exposure Is Associated with Decreased DNA Repair in Vitro and in Individuals Exposed to Drinking Water Arsenic. Environmental Health Perspectives. 114(8):1193-1198.
  • Andrew, Angeline S., Jefferey L. Burgess, Maria Mercedes Meza, Eugene Demidenko, Mary G. Waugh, Joshua W. Hamilton, and Margaret R. Karagas. 2006. Arsenic Exposure Is Associated with Decreased DNA Repair in Vitro and in Individuals Exposed to Drinking Water Arsenic. Environmental Health Perspectives. 114(8):1193-1198.
  • Andrew, Angeline S., Jefferey L. Burgess, Maria Mercedes Meza, Eugene Demidenko, Mary G. Waugh, Joshua W. Hamilton, and Margaret R. Karagas. 2006. Arsenic Exposure Is Associated with Decreased DNA Repair in Vitro and in Individuals Exposed to Drinking Water Arsenic. Environmental Health Perspectives. 114(8):1193-1198.
  • Andrew, Angeline S., Heather H. Nelson, Karl T. Kelsey, Jason H. Moore, Alexis C. Meng, Daniel P. Casella, Tor Devin Tosteson, Alan R. Schned, and Margaret R. Karagas. 2006. Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility. Carcinogenesis. (http://carcin.oupjournals.org/) Exit NIEHS Website 27(5):1030-1037.
  • Ayotte, J.D., Dalsu Baris, Kenneth P. Cantor, Joanne S. Colt, Gilpin R. Robinson, Jay H. Lubin, Margaret R. Karagas, Robert N. Hoover, Joseph F. Fraumeni, and Debra T. Silverman. 2006. Bladder cancer mortality and private well use in New England: an ecological study. Journal of Epidemiology and Community Health. (http://jech.bmj.com/) Exit NIEHS Website 60:168-172.
  • Ayotte, J.D., B.T. Nolan, J.R. Nuckols, Kenneth P. Cantor, Gilpin R. Robinson, Dalsu Baris, L. Hayes, Margaret R. Karagas, William Bress, Debra T. Silverman, and Jay H. Lubin. 2006. Modeling the Probability of Arsenic in Groundwater in New England as a Tool for Exposure Assessment. Environmental Science and Technology. (http://pubs.acs.org/journals/esthag/) Exit NIEHS Website 40(11):3578-85.
  • Karagas, Margaret R., Martin A. Weinstock, and Heather H. Nelson. 2006. Keratinocyte Carcinomas. Chapter 64 in: Cancer Epidemiology and Prevention (http://www.oup.com/us/catalog/general/subject /Medicine/EpidemiologyBiostatistics/~~/dmlldz 11c2EmY2k9OTc4MDE5NTE0OTYxNg==) Exit NIEHS Website. Oxford University Press, New York, NY.
  • Manuguerra, M., F. Saletta, Margaret R. Karagas, M. Berwick, F. Veglia, Paolo Vineis, and G. Matullo. 2006. XRCC3 and XPD/ERCC2 single nucleotide polymorphisms and the risk of cancer: a HuGE review. American Journal of Epidemiology. (http://www.aje.oupjournals.org/) Exit NIEHS Website 164(4):297-302.
  • Marsit, Carmen J., E. AndrĂ©s Houseman, B.C. Christensen, Karen Eddy, R. Bueno, D.J. Sugarbaker, Heather H. Nelson, Margaret R. Karagas, and Karl T. Kelsey. 2006. Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors. Cancer Research. (http://cancerres.aacrjournals.org/) Exit NIEHS Website 66(21):10621-9.
  • Marsit, Carmen J., Margaret R. Karagas, Hadi Danaee, Mei Liu, Angeline S. Andrew, Alan R. Schned, Heather H. Nelson, and Karl T. Kelsey. 2006. Carcinogen exposure and gene promoter hypermethylation in bladder cancer. Carcinogenesis. (http://carcin.oupjournals.org/) Exit NIEHS Website 27(1):112-116.
  • Marsit, Carmen J., Margaret R. Karagas, Alan R. Schned, and Karl T. Kelsey. 2006. Carcinogen exposure and epigenetic silencing in bladder cancer. Annals of the New York Academy of Science. (http://www.nyas.org/) Exit NIEHS Website 1076:810-21.
  • Rees, J.R., Stefan Sturup, C. Chen, Carol L. Folt, and Margaret R. Karagas. 2006. Toenail mercury and dietary fish consumption. Journal of Exposure Analysis and Environmental Epidemiology. (http://www.nature.com/jes/index.html) Exit NIEHS Website
2005
  • Hirao, Shuya, Tomoko Hirao, Yoko Hirao, Carmen J. Marsit, Alan R. Schned, Tara Devi-Ashok, Heather H. Nelson, Angeline S. Andrew, Margaret R. Karagas, and Karl T. Kelsey. 2005. Loss of heterozygosity on chromosome 9q and p53 alterations in human bladder cancer. Cancer. (http://www.interscience.wiley.com/canceronlin e) Exit NIEHS Website 104(9):1918-1923.
  • Karagas, Margaret R., Sunyeong Park, Heather H. Nelson, Angeline S. Andrew, Leila A. Mott, Alan R. Schned, and Karl T. Kelsey. 2005. Methylenetetrahydrofolate reductase (MTHFR) variants and bladder cancer: A population-based case-control study. International Journal of Hygiene and Environmental Health. (http://www.elsevier.de/ijheh) Exit NIEHS Website 208(5):321-327.
  • Karagas, Margaret R., Sunyeong Park, Amy Warren, Joshua W. Hamilton, Heather H. Nelson, Leila A. Mott, and Karl T. Kelsey. 2005. Gender, smoking, glutathione-S-transferase variants and bladder cancer incidence: a population-based study. Cancer Letters. (http://www.sciencedirect.com/science/journal/ 03043835) Exit NIEHS Website 219(1):63-69.
  • Kelsey, Karl T., Tomoko Hirao, Shuya Hirao, Tara Devi-Ashok, Heather H. Nelson, Angeline S. Andrew, Joanne S. Colt, Dalsu Baris, J. Steven Morris, Alan R. Schned, and Margaret R. Karagas. 2005. TP53 alterations and patterns of carcinogen exposure in a U.S. population-based study of bladder cancer. International Journal of Cancer. (http://www3.interscience.wiley.com/cgi-bin/jt oc?ID=29331) Exit NIEHS Website 117(3):370-375.
  • Marsit, Carmen J., Margaret R. Karagas, Angeline S. Andrew, Mei Liu, Hadi Danaee, Alan R. Schned, Heather H. Nelson, and Karl T. Kelsey. 2005. Epigenetic Inactivation of SFRP Genes and TP53 Alteration Act Jointly as Markers of Invasive Bladder Cancer. Cancer Research. (http://cancerres.aacrjournals.org/) Exit NIEHS Website 65(16):7081-7085.
  • Park, Sunyeong, Margaret R. Karagas, Amy Warren, Joshua W. Hamilton, and Karl T. Kelsey. 2005. Gender, smoking, glutathione-S-transferase variants and bladder cancer incidence: a population-based study. Cancer Letters. (http://www.sciencedirect.com/science/journal/ 03043835) Exit NIEHS Website 119(1):63-69.
2004
  • Andrew, Angeline S., Alan R. Schned, John A. Heaney, and Margaret R. Karagas. 2004. Bladder cancer risk and personal hair dye use. International Journal of Cancer. (http://www3.interscience.wiley.com/cgi-bin/jt oc?ID=29331) Exit NIEHS Website 109(4):581-586.
  • Carroll, Raymond J., David Ruppert, Tor Devin Tosteson, and Margaret R. Karagas. 2004. Nonlinear and nonparametric regression and instrumental variables. Journal of the American Statistical Association. (http://www.jstor.org/journals/01621459.html) Exit NIEHS Website 99(467):736-750.
  • Colt, Joanne S., Dalsu Baris, Patricia Stewart, Alan R. Schned, John A. Heaney, Leila A. Mott, Debra T. Silverman, and Margaret R. Karagas. 2004. Occupation and bladder cancer risk in a population-based case-control study in New Hampshire. Cancer Causes and Control. (http://www.ovid.com/site/catalog/Journal/1462 .jsp) Exit NIEHS Website 15(8):759-769.
  • Karagas, Margaret R., Tor Devin Tosteson, J. Steven Morris, Eugene Demidenko, Leila A. Mott, John A. Heaney, and Alan R. Schned. 2004. Incidence of transitional cell carcinoma of the bladder and arsenic exposure in New Hampshire. Cancer Causes and Control. (http://www.ovid.com/site/catalog/Journal/1462 .jsp) Exit NIEHS Website 15(5):465-472.
  • Kelsey, Karl T., Tomoko Hirao, Alan R. Schned, Shuya Hirao, Tara Devi-Ashok, Heather H. Nelson, Angeline S. Andrew, and Margaret R. Karagas. 2004. A population-based study of immunohistochemical detection of p53 alteration in bladder cancer. British Journal of Cancer. (http://www.nature.com/bjc/index.html) Exit NIEHS Website 90(8):1572-1576.
  • Kelsey, Karl T., Tomoko Hirao, Alan R. Schned, Shuya Hirao, Tara Devi-Ashok, Heather H. Nelson, Angeline S. Andrew, and Margaret R. Karagas. 2004. A population-based study of immunohistochemical detection of p53 alteration in bladder cancer. British Journal of Cancer. (http://www.nature.com/bjc/index.html) Exit NIEHS Website 90(8):1572-1576.
  • Kelsey, Karl T., Sunyeong Park, Heather H. Nelson, and Margaret R. Karagas. 2004. A Population-Based Case-Control Study of the XRCC1 Arg399Gln Polymorphism and Susceptibility to Bladder Cancer. Cancer Epidemiology Biomarkers & Prevention. (http://cebp.aacrjournals.org/) Exit NIEHS Website 13(8):1337-1341.
  • Wickre, Joel B., Carol L. Folt, Stefan Sturup, and Margaret R. Karagas. 2004. Environmental exposure and fingernail analysis of arsenic and mercury in children and adults in a Nicaraguan gold mining community. Archives of Environmental Health. (http://vnweb.hwwilsonweb.com/hww/Journals/get Issues.jhtml?sid=HWW:OMNIS&issn=0003-9896) Exit NIEHS Website 59(8):400-409.
2003
  • Andrew, Angeline S., Margaret R. Karagas, and Joshua W. Hamilton. 2003. Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking water. International Journal of Cancer. (http://www3.interscience.wiley.com/cgi-bin/jt oc?ID=29331) Exit NIEHS Website 104(3):263-268.
  • Andrew, Angeline S., Margaret R. Karagas, L. Klei, and Joshua W. Hamilton. 2003. Drinking water arsenic exposure is associated with decreased DNA repair gene expression. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 72(S1):184.
  • Tosteson, Tor Devin, Jeffery S. Buzas, Eugene Demidenko, and Margaret R. Karagas. 2003. Power and sample size calculations for generalized regression models with covariate measurement error. Statistics in Medicine. 22(7):1069-1082.
2002
  • Andrew, Angeline S., Margaret R. Karagas, Alan R. Schned, and Joshua W. Hamilton. 2002. Decreased expression of DNA repair genes ERCC1, XPF, and XPB, but not XPG or XPA among individuals exposed to arsenic in drinking water. In: Proceedings of the 93rd Annual Meeting of the American Association for Cancer Research, April 6-10, 2002. San Francisco, CA.
  • Andrew, Angeline S., Leila A. Mott, John A. Heaney, Alan R. Schned, and Margaret R. Karagas. 2002. Bladder cancer risk and personal hair dye use in women. In: Proceedings of the 93rd Annual Meeting of the American Association for Cancer Research, April 6-10, 2002. San Francisco, CA.
  • Colt, Joanne S., Dalsu Baris, S.F. Clark, J.D. Ayotte, M. Ward, J.R. Nuckols, Kenneth P. Cantor, Debra T. Silverman, and Margaret R. Karagas. 2002. Sampling private wells at past homes to estimate arsenic exposure: a methodologic study in New England. Journal of Exposure Analysis and Environmental Epidemiology. (http://www.nature.com/jes/index.html) Exit NIEHS Website 12(5):329-334.
  • Danaee, Hadi, Heather H. Nelson, Margaret R. Karagas, Alan R. Schned, Tara Devi-Ashok, Tomoko Hirao, Anne E. Perry, and Karl T. Kelsey. 2002. Microsatellite instability at tetranucleotide repeats in skin and bladder cancer. In: Proceedings of the 93rd Annual Meeting of the American Association for Cancer Research, April 6-10, 2002. San Francisco, CA.
  • Danaee, Hadi, Heather H. Nelson, Margaret R. Karagas, Alan R. Schned, Tara Devi-Ashok, Tomoko Hirao, Anne E. Perry, and Karl T. Kelsey. 2002. Microsatellite instability at tetranucleotide repeats in skin and bladder cancer. Oncogene. (http://www.nature.com/onc/) Exit NIEHS Website 21(32):4894-4899.
  • Karagas, Margaret R., H.A. Nelson, Karl T. Kelsey, S. Morris, Joel D. Blum, Tor Devin Tosteson, M. Carey, and X. Chris Le. 2002. Urinary Arsenic species in relation to drinking water and toenail arsenic concentrations and genetic polymorphisms in GSTM1 in New Hampshire. In: Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives (http://www.amazon.com/exec/obidos/tg/detail/- /1566705967/qid=1125592445/sr=1-1/ref=sr_1_1/ 102-5267823-2464935?v=glance&s=books) Exit NIEHS Website. CRC Press Company, Boca Raton, FL.
  • Karagas, Margaret R., H.A. Nelson, Karl T. Kelsey, S. Morris, Joel D. Blum, Tor Devin Tosteson, M. Carey, and X. Chris Le. 2002. Urinary arsenic species in relation to drinking water and toenail arsenic concentrations and genetic polymorphisms in GSTM1 in New Hampshire. Proceedings in Nucleic Research. 17:251-261.
  • Karagas, Margaret R., Therese A. Stukel, and Tor Devin Tosteson. 2002. Assessment of cancer risk and environmental levels of arsenic in New Hampshire. International Journal of Hygiene and Environmental Health. (http://www.elsevier.de/ijheh) Exit NIEHS Website 205(1-2):85-94.
  • Schned, Alan R., Margaret R. Karagas, and Karl T. Kelsey. 2002. Prevalence of bladder tumour types in a non-selected patient Population, classified according tothe World Health Organization/International Society of Urologic Pathologists(WHO/ISUP) System. Histopathology. 41(S1):52-53.
2001
  • Karagas, Margaret R., X. Chris Le, S. Morris, Joel D. Blum, Xiufen Lu, Vickie L. Spate, M. Carey, Virginia Stannard, Bjoern Klaue, and Tor Devin Tosteson. 2001. Markers of low level arsenic exposure for evaluating human cancer risks in a U.S. population. International Journal of Occupational Medicine and Environmental Health. 14(2):171-175.
  • Karagas, Margaret R., Therese A. Stukel, J. Steven Morris, Tor Devin Tosteson, Steven K. Spencer, and E. Robert Greenberg. 2001. Skin cancer risk in relation to toenail arsenic concentrations in a US population-based case-control study. American Journal of Epidemiology. (http://www.aje.oupjournals.org/) Exit NIEHS Website 153(6):559-565.
  • Park, S., Margaret R. Karagas, Heather H. Nelson, Leila A. Mott, Kali M. Bronson, and Karl T. Kelsey. 2001. X-ray repair cross-complementing gene 1 (XRCC1) polymorphisms and the risk of bladder cancer. In: Proceedings of the American Association for Cancer Research Annual Meeting, 2001.
2000
  • Karagas, Margaret R., Tor Devin Tosteson, Joel D. Blum, Bjoern Klaue, Julia E. Weiss, Virginia Stannard, Vickie L. Spate, and J. Steven Morris. 2000. Measurement of low levels of arsenic exposure: a comparison of water and toenail concentrations. American Journal of Epidemiology. (http://www.aje.oupjournals.org/) Exit NIEHS Website 152(1):84-90.
  • Tosteson, Tor Devin and Margaret R. Karagas. 2000. Designing an arsenic and bladder cancer case-control study. What sample size is needed to detect the beginning of dose-response?. Metal Ions in Biology and Medicine. 6:28-30.
1999
  • Peters, S.C., Joel D. Blum, Bjoern Klaue, and Margaret R. Karagas. 1999. Arsenic occurrence in New Hampshire drinking water. Environmental Science and Technology. (http://pubs.acs.org/journals/esthag/) Exit NIEHS Website 33(9):1328-1333.
1998
  • Karagas, Margaret R., Tor Devin Tosteson, Joel D. Blum, J. Steven Morris, John A. Baron, and Bjoern Klaue. 1998. Design of an epidemiological study of drinking water arsenic exposure and cancer risk in a US population. Environmental Health Perspectives. 106Suppl.4:1047-1050.
  • Nichols, T.A., J. Steven Morris, M.M. Mason, Vickie L. Spate, Connie K. Baskett, T.P. Cheng, C.J. Tharp, J.A. Scott, T.L. Horsman, A.E. Tawson, Margaret R. Karagas, and Virginia Stannard. 1998. The study of human nails as an intake monitor for arsenic using neutron activation analysis. Journal of Radioanalytical and Nuclear Chemistry. (http://www.kluweronline.com/issn/0236-5731/co ntents) Exit NIEHS Website 236:51-56.
1996
  • Karagas, Margaret R., J. Steven Morris, Julia E. Weiss, Vickie L. Spate, Connie K. Baskett, and E. Robert Greenberg. 1996. Toenail samples as an indicator of drinking water arsenic exposure. Cancer Epidemiology Biomarkers & Prevention. (http://cebp.aacrjournals.org/) Exit NIEHS Website 5(10):849-852.
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Last Reviewed: 19 May 2008