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Model Name / Model Descriptor:
PI's Name:
Abate-Shen, Cory
Aguet*, Michel
Al-Ubaidi, Muayyad
Almholt, Kasper
Altavilla, Giuseppe
Altschuler, Daniel
Ananthaswamy, Honnavara
Arbeit, Jeff
Arnold, Andrew
Artavanis-Tsakonas, Spyros
Arteaga, Carlos
Baker, Suzanne
Balmain, Allan
Barlow, Carrolee
Baron, Beverly
Basson, Craig
Baylin, Stephen
Ben-Neriah, Yinon
Benezra, Robert
Berns, Anton
Bertagnolli, Monica
Besmer*, Peter
Betz*, Ulrich
Birchmeier*, Walter
Blasco, Maria
Bradley, Allan
Bremner, Rod
Brindle*, Paul
Brinster*, Ralph
Brown, Powel
Bulavin, Dmitry
Capecchi*, Mario
Caulin, Carlos
Cavallo, Federica
Cheng, Sheue-yann
Cherrington, Julie
Chin, Lynda
Chodosh*, Lewis
Christofori, Gerhard
Chu, Fong-Fong
Cleary, Margot
Clevers, Hans
Coffey, Robert
Collins, Francis
Cory, Suzanne
Costa, Robert
Coussens, Lisa
Croce*, Carlo
Curran, Tom
Dagli, Maria Lúcia Zaidan
Dai, Wei
DePinho, Ronald
Deng, Chu-Xia
Dickson, Robert
Dittmer, Dirk
Doetschman, Tom
Donehower, Larry
Dragani, Tommaso
Druker, Brian
Dymecki*, Susan
Edlund*, Helena
Efstratiadis, Argiris
Eischen, Christine
Elgavish, Ada
Elias*, Jack
Epstein, Jonathan
Ernst, Matthias
Evans, Ronald
Felsher, Dean
Fishman*, Glenn
Flavell*, Richard
Fodde, Riccardo
Fuchs*, Elaine
Fujimori, T
Furth, Priscilla
Förster*, Irmgard
Gallego, Marta
Gendler, Sandra
Ghezzo, Franco
Giraud, Andrew
Glickman, Lawrence T
Glimcher, Laurie
Goettlicher, Martin
Gonzalez*, Frank
Goodlad*, Robert
Gordon, Jennifer
Grady*, William
Graessmann, Adolf
Graham, Chris
Green, Jeff
Greenberg, Norman
Greiner, John
Gress, Ronald
Grupp, Stephan
Gu, Guoqiang
Gutkind, Silvio
Gutmann, David
Hanahan, Douglas
Harris, Curtis
Hatina, Jiri
Hayward, Nicholas
Heintz, Nathaniel
Heisterkamp, Nora
Hennighausen, Lothar
Herlyn, Meenhard
Holland, Eric
Hung, Mien-Chie
Hynes, Richard
Iavarone, Antonio
Ikeda, Hidetoshi
Ittmann*, Michael
Iwamoto*, T
Jacks, Tyler
Jaenisch*, Rudolf
Janz, Siegfried
Jensen, Roy
Jerry, Joseph
Jonkers*, Jos
Kaestner, Klaus
Kamel-Reid, Suzanne
Karin, Michael
Kato, Masashi
Kaufman, Howard
Kelavkar, Uddhav
Kemp, Christopher
Keri, Ruth
Khalili, Kamel
Khanna, Chand
Klausner, Jeffrey S.
Knutson, Keith
Kogan, Scott
Koller*, Beverly
Kong*, Ah-Ng Tony
Kucherlapati, Raju
Kwiatkowski, David
Lambert, Paul F.
Lampe, Paul
Lanza-Jacoby, Susan
Largaespada, David
Leder, Philip
Lee, Wen-Hwa
Lee, Eva Y-H. P.
Levine, Beth
Ley, Timothy
Li, Yi
Liang, Jake
Libutti, Steven
Lin, Li-Min
Lisanti, Michael
Lollini, Pier-Luigi
Look*, Thomas
Lopez-Revilla, Ruben
Lowe*, Scott
Lowell*, Bradford
Lozano, Guillermina
Mackay, Fabienne
Macpherson, David
Magnuson*, Mark
Mak, Tak
Malkinson, Alvin
Markowitz*, Sanford
Marth*, Jamey
Martin, Keith
Martin*, Gail
Matusik, Robert
Matzuk*, Martin
McDonald, Donald
McKeehan, Wallace
Medina, Daniel
Melton, David
Menck, Carlos
Merlino, Glenn
Michaud, Edward
Miller, MS
Miyazaki*, Jun-ichi
Mizumoto*, Kazuhiro
Morris, John
Morris, J Steven
Morse , Herbert
Moser, Amy
Moses*, Harold
Mukaida, Naofumi
Mukherjee, Pinku
Mukhtar, Hasan
Muller, William
Muller-Decker*, Karin
Murray, Timothy
Muscarella, Peter
Nakashima*, Jun
Namba*, Hiroyuki
Navarro, Pilar
Nestler*, Eric
Nilsson, Jonas
Noda*, Tetsuo
Obradovich, Joyce E
Olson*, James
Orsulic, Sandra
Oshima, Robert
Pandolfi, Pier Paolo
Parada, Luis
Parsons*, Ramon
Pendás, Alberto
Pestell, Richard
Pitot, Henry C.
Porter, Carl
Pravtcheva, Dimitrina
Pritchard, Catrin
Proia*, Richard
Putzer, Brigitte
Rajewsky*, Klaus
Raveche, Elizabeth
Reber, Howard
Reed, John
Ren, Mingqiang
Resar, Linda
Reynolds*, Albert
Rigas, Basil
Robine*, Sylvie
Rodriguez-Puebla, Marcelo
Roop*, Dennis
Rosen, Jeff
Rosenbaum*, Jean
Ross, Jeff
Roy-Burman, Pradip
Rueda, Bo
Rustgi, Anil
Sabaawy, Hatem
Salomon, David
Sawyers, Charles
Schmidt, Emmett
Schreiber-Agus, Nicole
Schuetz*, Guenther
Schwartz*, Robert
Sebti, Saïd
Sellers, William
Sena-Esteves, Miguel
Serrano, Manuel
Sexl, Veronika
Shannon, Kevin
Shen*, Michael
Sherr, Charles
Shull, James
Singh, Pomila
Singh*, Harinder
Soriano, Philippe
Spencer, David
Stambrook, Peter
Strasser*, Andreas
Stratakis, Constantine
Strieter, Robert
Stringer, James
Suckow, Mark
Takeda*, Junji
Taketo, Makoto
Tekmal, Rajeshwar
Tenen, Daniel
Tew, Kenneth
Threadgill, David
Toftgard, Rune
Toubeau*, Gerard
Tronche*, Francois
Tsarfaty*, Ilan
Tuveson, David
Uckun, Fatih
Van Dyke, Terry
Varmus, Harold
Vasioukhin, Valeri
Verhoeven*, Guido
Waalkes, Michael
Wagner, Kay-Uwe
Wagner*, Erwin
Wainwright*, Brandon
Wali, Ramesh
Walker, Nigel
Wang, Fen
Wang, Xiao-Jing
Wang, Timothy
Wang*, Zhi
Ward, Jerrold
Watt, Fiona
Wei, Wei-Zen
Weiss, William
Weissenberger, Jakob
Welsh, JoEllen
Westphal*, Heiner
Wolchok, Jedd D
Wolff, Linda
World Wide Web (URL: http://www.informatics.jax.org/), (July 2006)
Wright, Kenneth C.
Wu, Xue-Ru
Wu, Hong
Xiao, Hua
Xie, Jingwu
Xu, Jianming
Yamada, Yoshihiko
Yamamoto, Masayuki
Yamamura*, Ken-ichi
Yamasaki, Lili
Yamazaki, Fumikazu
Yang, Xiao
Yla-Herttuala*, Seppo
Yoshimura, Akihiko
Zhu, Huanzhang
Zimmer*, Andreas
Zon, Leonard I
Zornig, Martin
van Deursen, Jan
van Steeg, Harry
Species:
Dog (Canis familiaris)
Hamster (Mesocricetus auratus)
Mouse (Mus musculus)
Rat (Rattus norvegicus)
Rat (Rattus rattus)
Zebrafish (Danio rerio)
Site of Lesion/Tumor:
Diagnosis:
Phenotype:
Phenotype:
Publication:
PubMed Identifier:
Genetic Description:
Models with Transgene
Check here to search for models with
trangene data
Transgene Name:
activated c-Ha-ras
agouti
Akt
Akt1
Aromatase
BAFF
Bcl-2
bcl-2
Bcl-XL
BCL2
Bcl2
bcl2
BCL6
BCR-ABL
BCR/ABL P190
beta catenin
beta-gal
Bmi1
BRAF
BRCA1 floxed
c-erb-B2
c-fms
c-myc
c-Neu
c-neu
C3(1)/SV40 Tag
CDK4
cdk4
CEA
COX-2
cox2
CRD-BP
Cre
cre
Cre recombinase
cre*PR1
Cre,Luciferase
cre-IRES-GFP
crePR1
Cripto-1
CSF1
cyclin D1
Cyclin D1 cDNA
cyclin D1 cDNA
DeltaNbeta-cateninER
deltaNLef1
deltaV-TCRbeta
des-IGF-1
dl1137 (T121)
dsRED2
E7
EGFP
EGFP-TEL-AML1 fusion
Erbb2
Erbb2 (Neu)
ES-4 allele of v-erbB
FADD-DN
FGF7
FGFR1
Fgfr1
FGFR2
FGFR2iiib
FLP
Flp
FLT3(W51)
Frat1
FRP/RET fusion gene
G12V-Rap1b
Gastrin
GFP
GLp65 (yeast GAL4 and NF kapaB p65)
Glycine-extended gastrin
H-RAS
H-Ras
H-RAS (G12V)
H-ras mutant (human valine 12)
H-RAS V12
Ha-ras
HBV large-envelope polypeptide
HBV surface antigen protein (HBsAg)
HBV X protein (HBx)
hDTX1
hepatitis B virus X gene
Hepatocyte growth factor/scatter factor
hepsin
Her-2
HGF/SF
histidine tagged MYC
Hmg-i
hN1
Hoxa9
HPV16
HPV16 E6
HPV16 E7
HPV16 early region
HRAS
HRAS v12
HRASv12
Human Papillomavirus Type 16 Early Region
human polyomavirus, JC virus (JCV) T-antigen
I kappaB alpha
IkappB-alpha
IL1R1
IL6
Ink4a/Arf
Insulin-like growth factor (IGF-2)
Insulin-like growth factor II (Igf-2)
int2
integrin alpha 2
integrin alpha 3
integrin alpha6
integrin beta 1
integrin, beta 4
JCV T-antigen
JCV(CY) T-antigen
K-Ras<sup>V12</sup>
K14-HPV16 entire early region bp97 to 6152
KGF (Keratinocyte growth factor )
Kras
L-myc
LANA (ORF73)
Large T antigen
Large T antigen (SV40)
large-T antigen of SV40
Luc-IRES-EGFP
luciferase
luteinizing hormone beta subunit
MEK1 with two phospho-mimetic point mutations (S217E/S221E)
Met
mPGES-1
Mt-1
MUC1
mutant TP53
MYC
Myc
myc
MYCN
NDF/heregulin
neomycin phosphotransferase (neo) gene
Neu
neu
NEU (activated)
neu (LOC362204)
Neu/Her-2
NGF
nls-lacZ
Ntv-a
NuMA-RARalpha
p16
p210 BCR-ABL1
p53
p53(R172L)
Pim1
Pim2
PLAP
PLZF-RARalpha
PML
PML-RARA
PML-RARalpha
polyoma virus middle T antgen
Polyoma virus middle T antigen
polyomavirus middle T antigen (PVMT)
Prkar1a exon 2 (X2AS)
progastrin
PyMT
PymT, polyomavirus middle T antigen
PyT (Polyoma Virus middle T oncogene)
PyVT
RAR alpha
RARalpha-PLZF
RET
ret
ret proto-oncogene
RET51
reverse tetracycline transactivator (rtTA)
reverse tetracyline-controlled transactivator protein (rtTA)
RIP1-Tag
rTA
rtTA
SCF
SmoA1
Son of Sevenless (SOS-F)
SSAT (LocusID: 20229)
SV11
SV40 early genes
SV40 early genes (T/t antigens)
SV40 early region (SVER)
SV40 Large T antigen
SV40 large T antigen (Tag)
SV40 T antigen
SV40 T antigen (Tag)
SV40 TAg
SV40 Tag
SV40-Tag
SV40/TAg
SV40TAg
SV40Tag
tat
TCL1
TEL-AML1 fusion
Tert
tet repressor-VP16 (tetRVP16)
tet repressor-VP16 (tTA)
tet repressor-VP16 fusion protein (tetRVP16)
tetracycline responsive transactivator (tTA)
tetracycline-transactivating protein (tTA)
TGF alpha
TGF beta1
TGF-beta II receptor
the tet repressor-VP16 fusion protein (tetRVP16)
TIMP1
Tpr-Met
TRAF2DN, mutant Traf2
trans-activating protein (tTA)
Truncated kinase-defective TGF beta type II receptor
tTA
tv-a
Tyr
v-Ha-ras
v-jun
v-src
VEGF
vH-ras
VpPPAR gamma
Wnt 1
Wnt-1
Wnt1
X-noggin
Models with Targeted Modification
Check here to search for models with
targeted modification data
Targeted Modification Gene Name:
AIB1
AIB3
alfa-E-catenin
alpha-catenin
ameloblastin
APC
Apc
Apc1638N
Aprt
AR
Arf
Arnt
Aryl-hydrocarbon receptor (Ahr)
Atm
B-Raf
B-raf
Bax
Bcl-x
Bdnf
beclin 1
beta catenin
beta-catenin(ex3-6)
beta-galactosidase
Bim
Blm
Brca1
Brca2
BubR1
C kit
c Kit ligand
c-Cbl
c-jun
cables
Catnb
Cav-1
CBP
CD1d
Cdh1
Cdkn1b (encoding p27KIP1)
Cdkn2a
Cdnk2a
Cdx2
chloramphenicol acetyl-transferase (CAT)
cPLA2
Cx32
Cx43
CXCR2
cyclin D1
Dmp1
DNA Ligase 1
Dnmt1
Dnmt3b
Dpc4
dsRED2
E-selectin
E2F-1
EP1
EP2
EP3
EP4
Ereg
Fbxw7
Fgf4
Fgf8
fgf8
Fhit
Foxl1
Foxm1b
gastrin
GATA-1
gene trap ROSA 26
gp130
Gpx1
Gpx2
GSTp1
GSTp2
Gt(ROSA)26Sor<sup>tm1(cre/ESR1)Tyj </sup>
Hic1
Id2
IFN-gama
Ig micro-chain
IKK beta
IL-2gamma
IL10
Il1r1
IL6
Ink4a
INK4a/ARF
Ink4a/ARF
Ink4a/Arf
ink4a/arf
integrin beta 3
integrin beta 5
JNK2
K-ras
K14
Kit
Kras
L-selectin
leptin
leptin receptor
Lkb1
Mad2
mdm2
Mdr2
Men1
Men1 (exons 3-8)
Mlh1
Mmp19
Mmp8
Msh2
Msh3
Msh6
Mt1
Mt2
mTR
Muc 1
Mzf1
NCAM
neomycin phosphotransferase (neo) gene
neutrophil elastase (NE)
Nf1
Nkx3.1
Nos2
Notch1
Nrf2
P selectin
p107
p120
p15Ink4b
p16In4a (aka cdkn2a, MTS-1)
p16Ink4a (aka cdkn2a, MTS-1)
p16Ink4a (aka MTS-1, cdkn2a)
p19 ARF
p19ARF
p21
p27
p300
p53
p53
PAI-1
Pgdh
PLZF
PML
Pml
Pol<i>beta</i>
polb
Ppara
PPARdelta
Pparg
Ppm1d
prkar1a
Ptc
Ptch1
Pten
Ptgs2
PU.1
Rad52
Rag2
RASSF1A
RB
Rb
Rb (exon 19)
Rb1
Retinoblastoma (Rb)
Sfpi1
Smad 3
Smad4
Socs1
T bet
TGF-beta II receptor
TGF-beta IIR
Tgfb1
Tgfbr2
Tip30
TNF
TNF-Rp55
Tnfr1
tPA
tpr53
TRbeta
Trp53
Trp53 <sup>tm1Brd</sup>
Tsc1
Tslc1
TYK2
Ugcg
uPA
UTI
VDR
Xpa
Genomic Segment Designator:
PTH-D1
Carcinogenic Interventions:
Select Carcinogenic Agent Type:
Antibody
Bacteria
Chemical / Drug
Environment
Growth Factor
Hormone
Nutrition
Other
Plasmid
Radiation
Transposon
Viral
Select Carcinogenic Agent Name:
Cell Lines
Cell Line:
ANV
B-1 malignant cell
B106
B112
B113
B114
B117
B119
B132
B139
B140
B160
B186
B190
BS-1B13
BS-1B14
BS-1B7
BS-1B8
BS-1a
BS-1b
BS-1c
BS-1f
C1, C2, T1, T2
CMV-TETO GFP-Foxm1b U2OS clone C3 cell line
ES 164
FLT3W51
H2T
JUN-1
JUN-2
JUN-3
KL5B
KL5N
L1-3 (normal)
L15_Msh2-/-
L23 (tumor)
L25 (tumor)
L37 (normal)
L55 (normal)
L57 (normal)
L61 (normal)
M6
MEF_Msh2+/-_E7/Ras
MEF_Msh2+/-_mp53
MEF_Msh2-/-_E7/Ras
MEF_Msh2-/-_mp53
MMC
NE-CS
NMH-delta202,AMH-delta202,TAMH-delta202,
NP cis
PLC1
PR-111
PR-117
PR-14
R25_Msh2-/-
R545
R545-VEGF/GFP
SJMM1
SJMM2
Smad4 -/-
TG1124
TG5928
TRAMP-C1
TRAMP-C2
TRAMP-C3
TUBO
Transplantable MRP8-PMLRARA Leukemias
W525,0069,780
YD A15, YD A19
bmn1
p53+/- MEFs
p53-/-mdm2-/-
p53-LSL
unable to establish cell lines from lung tumors
Therapeutic Approaches
Models with Therapeutic Approaches
Check here to search for models with
therapeutic approaches data
Compound/Drug:
3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate] (Compound 003)CAS 149560-32-7,
4-Hydroxytamoxifen
9-cis-retinoic acid
ABT-510 1.0 mg/kg
ABT-510 12.5 to 17.5 mg
ABT-526 0.5 mg/kg
ABT-526 12.5 mg
AG013736 and VEGF-Trap
AZD2171
Ad.Neu-Modified Dendritic Cells
Ad.RET(DeltaTK)
Arsenic Trioxide
BB94
Bikunin
CA-4P
CEA vaccines
CEA-based vaccine
COX-1 inhibitor, SC560
COX-2 inhibitor, celecoxib
Celecoxib
Celecoxib (Cox2 inhibitor)
DFMO
DHEA
Doxil plus placebo
Doxil plus pyridoxine
EB1089
Endostatin
F10 (bovine red blood cell ubiquitin)
F14 (14kDa fraction of UK101)
F50 (50 kDa fraction of UK101)
FLT3 inhibitor
FTase inhibitor FTI-2148
Geranylgeranyltransferase I Inhibitor GGTI-2154
HhAntag
IL 12
IL-10 antisense
IL-2 liposomes
IL12
Imatinib
LGD1069 (RXR-selective retinoid)
LGD1069 (retinoid X receptor-selective retinoid)
MK886
N-acetyl-L-cysteine (NAC)
N<sup>G</sup>-nitro L-arginine methyl ester
NO-donating aspirin
Neu-specific monoclonal antibody 7.16.4
PBS (phosphate-buffered saline)
PEG 3350
PPI omeprazole
Pfaffia paniculata (Brazilian ginseng)
RFA (radio frequency ablation)
Rapamycin [53123-88-9]
Retinoic Acid
SCH66336
SU11654 (Small Molecule Receptor Tyrosine Kinase Inhibitor)
Sasa health
Suberoylanilide hydroxamic acid (SAHA)
Sulforaphane
Sulindac
TTNPB (retinoic acid receptor-selective retinoid)
UK101
VPA
YF476 (CCK2/gastrin receptor antagonist)
ZD1839 (gefitinib or Iressa)
all trans retinoic acid (ATRA)
allogeneic Neu/H-2<sup>q</sup> (expressed high levels of p185<sup>neu</sup>) mammary carcinoma cells
alpha-interferon
aminoguanidine
arsenic trioxide
celecoxib
cisplatin
cisplatin plus piroxicam
cox-2 selective inhibitor MF tricyclic
cyclopamine
cytoxan (CTX)
dehydroxymethylepoxyquinomicin (DHMEQ)
difluourmethylornithine (DFMO)
doxorubicin (DXR)
farnesyl transferase inhibitor
fludarabine
future therapeutic uses
gemcitabine
halofuginone
histone deacetylase inhibitors
histone deacetylase inhibitors and all-trans retinoic acid
human interferon beta (hIFN-beta) contralateral treatment
human interferon beta (hIFN-beta) dose response
human interferon beta (hIFN-beta) on established tumors
human interferon beta (hIFN-beta) pre-treatment
human tyrosinase
ibuprofen
indomethacin
low-fat and high-fiber diet
loxtidine (irreversible histamine H2-receptor antagonist)
monoclonal anti-c-Kit antibody (ACK2)
p185EC-TM Plasmids
p19ARF peptide with membrane transduction sequence
paclitaxel
polyphenolic fraction isolated from green tea (GTP)
r14 (recombinant protein F14)
rapamycin
rapamycin (sirolimus) every day
rapamycin (sirolimus) every other day
rapamycin+doxorubicin (DXR)
selenium (high-selenium yeast)
selenium (selenomethionine) high dose
selenium (selenomethionine) low dose
soluble Fc:T(beta)RII
tamoxifen
Histopathology
Models with Metastasis
Check here to search for models with Metastasis
Transient Interference
Transient Interference
Check here to search for models with transient interference data
Microarray Data
Microarray Data
Check here to search for models with microarray data
Image Data
Image Data
Check here to search for models with images
Tool Strain
Tool Strain
Check here to search for tool strains
(A tool strain is a strain that does not develop cancer,
but can be used to create cancer-bearing models. Example: strain carrying a floxed gene)
Data from External Sources
External Data Source:
Jax MTB
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