Logos and Walkers

Sequence logos and walkers. At the top of the figure sequence logos for human donor and acceptor sites depict the DNA sequence conservation by stacks of letters. Within each stack, the height of each letter is proportional to the base frequency at that position in the binding site. The height of each stack is the sequence conservation in bits of information. Below the sequence logos five examples of individual binding sites are shown as walkers. The height of each letter shows its contribution to the average sequence conservation in the sequence logo on the top. This figure is the cover of Nucleic Acids Research Volume 25, Issue 21, 1997.

• Large version of this figure
• The paper is Sequence Walkers: a graphical method to display how binding proteins interact with DNA or RNA sequences", Nucl. Acids Res., 25 4408-4415, 1997
• The mathematics for walkers is given in: Schneider TD (1997) Information content of individual genetic sequences. J. Theor. Biol. 189(4):427-441
• Movie of a walker
• Further information about walkers and associated software

Schneider Lab.
origin: 1998 January 1
updated: 1999 March 3