1. H. G. Kim, T. Wang,
P. Olafsson, and B. Lu. (1994) Neurotrophin-3
potentiates neuronal excitability and inhibits g-aminobutyratergic
synaptic transmission in cortical neurons. Proc. Natl. Acad. Sci.
USA 91, 12341-12345.
2. T. Wang, Z. Xie, and B. Lu, (1995) Nitric
oxide mediates activity-dependent synaptic suppression at developing neuromuscular
synapses. Nature 374, 262-266.
3. P. Olafsson, T. Wang, and B. Lu. (1995) Molecular
cloning and functional characterization of Xenopus Ca2+- binding protein
frequenin. Proc. Natl. Acad. Sci. USA 92, 8001-8005.
4. T. Wang, K. Xie, and B. Lu. (1995) Neurotrophins
promote maturation of developing neuromuscular synapses. J. Neurosci.
15, 4796-4805.
5. A. Figurov, L. Pozzo-Miller, T. Wang, P. Olafsson, and B. Lu. (1996)
Regulation
of synaptic responses to high-frequency stimulation and LTP by neurotrophins
in the hippocampus. Nature 381, 706-709.
6. P. Olafsson, H. D. Soares, K-H. Herzog, T. Wang, J. I. Morgan, and
B. Lu. (1997) The
Ca2+ binding protein, frequenin is a nervous system-specific protein in
mouse preferentially localized in neurites. Mol. Brain Res. 44, 73-82.
(pdf)
7. K. Xie, T. Wang, P. Olafsson, K. Mizuno, and B. Lu. (1997) Activity-dependent
expression of NT-3 in muscle cells in culture: Implications in the development
of neuromuscular junctions. J. Neurosci. 17, 2947-2958. (pdf)
8. C. -Y. Wang, J. Ni, H. Jiang, T. -A. Hsu, M. Dugich-Djordjevic, L.
Feng, M. Zhang, L. Mei, R. Gentz, and B. Lu. (1998) Cloning
and characterization of glial cell line-derived neurotrophic factor receptor
beta: A novel receptor for members of glial cell line-derived neurotrophic
factor family of neurotrophic factors. Neurosci. 83, 7-14. (pdf)
9. W. A. Gottschalk, L. Pozzo-Miller, A. Figurov, and B. Lu. (1998) Presynaptic
modulation of synaptic transmission and plasticity by brain-derived neurotrophic
factor in the developing hippocampus. J. Neurosci. 18, 6830-6839.
(pdf)
10. L. Pozzo-Miller, W. A. Gottschalk, L. Zhang, K. McDermott, J. Du,
R. Gopalakrishnan, C. Oho, Z. Sheng, and B. Lu. (1999) Impairments
in high frequency transmission, synaptic vesicle docking and synaptic
protein distribution in the hippocampus of BDNF knockout mice. J.
Neurosci. 19, 4972-4983. (pdf)
11. L. Feng, C. Wang, H. Jiang, C. Oho, M. Dugich-Djordjevic, L. Mei,
and B. Lu. (1999) Differential
signaling of glial cell line-derived neurotrophic factor and brain-derived
neurotrophic factor in cultured ventral mesencephalic neurons. Neuroscience.
93, 265-273. (pdf)
12. L. Feng, C. Wang, H. Jiang, C. Oho, K. Mizuno, M. Dugich-Djordjevic,
and B. Lu. (1999) Differential
effects of GDNF and BDNF on cultured ventral mesencephalic neurons.
Mol. Brain Res. 66, 62-70. (pdf)
13. W. A. Gottschalk, H. Jiang, N. Tartaglia, C. Oho, L. Feng, A. Figurov,
and B. Lu. (1999) Signaling
mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus.
Learning and Memory. 6, 243-256. (pdf)
14. X. He, F. Yang, Z. Xie, and B. Lu. (2000) Intracellular
Ca2+ and Ca2+/calmodulin dependent kinase II mediate acute potentiation
of neurotransmitter release by neurotrophin-3. J. Cell Biol. 149,
783-791. (pdf)
15. B. Xu, W. Gottschalk, A. Chow, R. I. Wilson, E. Schnell, K. Zang,
D. Wang, R. A. Nicoll, B. Lu, L. F. Reichardt. (2000) The
role of BDNF receptors in the mature hippocampus: Modulation of long-term
potentiation through a presynaptic mechanisms involving TrkB. J. Neuroscience
20, 6888-6897. (pdf)
16. J. Du, L. Feng, F. Yang, and B. Lu. (2000) Activity
and Ca2+-dependent modulation of surface expression of BDNF receptors
in hippocampal neurons. J Cell Biol. 150, 1423-1433. (pdf)
17. F. Yang, X. He, L. Feng, K. Mizuno, X. Liu, J. Russell, W. Xiong,
and B. Lu. (2001) Phosphoinositide-3
kinase and IP3 are both necessary and sufficient to mediate NT3-induced
synaptic potentiation. Nature Neurosci. 4, 19-28. (pdf)
18. F. Yang, L. Feng, F. Zheng, S. W. Johnson, J. Du, L. Shen, C. -P.
Wu, and B. Lu. (2001) GDNF
acutely modulates neuronal excitability and A-type potassium channels
in midbrain dopaminergic neurons. Nature Neurosci. Published online
10/2/01. (pdf)
19. C. Wang, F. Yang, X. He, A. Chow, J. Du, J. Russell, and B. Lu. (2001)
Ca2+-binding
protein frequenin mediates GDNF-induced synaptic facilitation by potentiation
Ca2+ channels and transmitter release. Neuron 32, 99-112. (pdf)
20. N. Tartaglia, J. Du, W. J. Tyler, E Neale, L Pozzo-Miller and B. Lu.
(2001) Protein
synthesis dependent and independent regulation of hippocampal synapses
by brain-derived neurotrophic factor. J. Biol. Chem. 276, 37585-37593.
(pdf)
21. L. Shen, J. G. Pichel, T. Mayeli, H. Sariola, B. Lu and H. Westphal (2001) GDNF haploinsufficiency causes Hirschspung-like intestinal obstruction and early onset lethality in mice. Am. J. Human Genetics 70, 435-447. (pdf)
22. C. Wang, F. Yang, X. He, , H.-S. Je, J.-Z. Zhou, K. Eckermann, D. Kawamura, L. Shen, and B. Lu. (2002) Regulation of Neuromuscular Synapse Development by Glial Cell Line-derived Neurotropic Factor and Neurturin. J. Biol. Chem. 277(12), 10614-10625. (pdf).
23. Z. G. Luo, Q. Wang, J. Z. Zhou, J. B. Wang, M. Y. Liu, X. He, A. Wynshaw-Boris, W. C. Xiong, B. Lu, and L. Mei (2002) Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1. Neuron 35, 489-505.(pdf)
24. D. E. Cabin, K. Shimazu, D. Murphy, N. Cole, W. A. Gottschalk, K. McIlwain, B. Orrison, A. Chen, L. Garret, C. Ellis, R. Paylor, B. Lu (co-corresponding author) and R. L. Nussbaum (2002) Synaptic vesicle depletion in mice lacking alpha-synuclein. J. Neurosci. 22, 8797-8807. (pdf)
25. R. Hashimoto, N. Takei, K. Shimazu, L. Christ, B. Lu, and D.-M. Chuang. (2002) Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity. Neuropharmacology, 43, 1173-1179. (pdf)
Reviews and Book Chapters (back to top)
1. B. Lu, M. Yokoyama,
C. F. Dreyfus and I. B. Black. (1991) Nerve growth factor gene expression
in actively growing brain glia. In: F. Hefti, Ph. Brachet, B. Will and
Y. Christen (Eds) Growth factors and Alzheimer's disease. Springer-Verlag.
Berlin. p61.
2. B. Lu and W. -m. Fu. (1995) Regulation of postsynaptic responses by
calcitonin gene-related peptide and ATP at developing neuromuscular junctions.
Can. J. Phyiol. & Pharmacol. 73, 1050-1056.
3. B. Lu and W. Gao (1997) The use of neurotrophic factors as novel therapeutic
agents for diseases in the nervous system. In "Guide to research
and Development of New Drugs" Ed. H. Zhou, R. W. Zhang Health and
Science Press. Beijing, China. 1997. 315-323.
4. L. Shen, A. Figurov, and B. Lu (1997) Recent progress in studies of
neurotrophic factors and their clinical implications. J. Mol. Medicine
75, 637-644. (pdf)
5. B. Lu, and A. Figurov. (1997) Role of neurotrophins in synapse development
and plasticity. Reviews in The Neuroscience. 8, 1-12.
6. W. Gao, M. M. Dugich-Djordjevic, R. J. Weil and B. Lu. (1997) Therapeutical
usage of neurotrophic factors: patent analysis. Expert Opinion on Therapeutic
Patents. 7, 325-338.
7. B. Lu, and A. Chow (1999) Neurotrophins and hippocampal synaptic plasticity.
J. Neurosci. Res. 58, 76-87. (pdf)
8. B. Lu, and W. Gottschalk (2000) Regulation of in hippocampal synaptic
plasticity by neurotrophins. Progress in Brain Res. 128, 231-241.
9. B. Lu, (2000) Neurotrophic regulation of synapse development and plasticity
by. Progress in Natural Sciences. 43, 1-5.
