The Ins and Outs of Glutamate Receptor Synaptic Trafficking |
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| Launch in standalone player | |
| Air date: | Monday, March 03, 2008, 12:00:00 PM |
| Category: | Neuroscience |
| Runtime: | 75 minutes |
| NLM Title: | The ins and outs of glutamate receptor synaptic trafficking [electronic resource] / Roger Nicoll. |
| Series: | NIH neuroscience seminar series |
| Author: | Nicoll, Roger A. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2008] |
| Other Title(s): | NIH neuroscience seminar series |
| Abstract: | (CIT): The Robert Whitney Newcomb Memorial Lecture Dr. Nicoll's lab is interested in elucidating the cellular and molecular mechanisms underlying learning and memory in the mammalian brain. Long-term potentiation (LTP), a phenomenon in which brief repetitive activity causes a long lasting (many weeks) enhancement in the strength of synaptic transmission, is generally accepted to be a key cellular substrate for learning and memory. His lab uses a combination of electrophysiological and molecular techniques to elucidate the molecular basis of LTP. They have found that LTP involves the rapid activity-dependent trafficking of glutamate receptors to the synapse. This trafficking requires the interaction of two families of synaptic proteins. One family is a novel group of proteins that, they discovered which bind to glutamate receptors and act as auxiliary subunits. These proteins are not only essential for the trafficking of the glutamate receptors, but also control the gating of the receptor channel. The other family is comprised of a family of scaffolding proteins that bind to the auxiliary subunits and thereby anchor the receptors at the synapse. Much of the current work in Dr. Nicoll's lab is focused on how activity controls this receptor trafficking and how the increase in synaptic strength during LTP is stabilized and maintained. The Robert W. Newcomb Memorial Fund was established by the Newcomb family in honor of their beloved son and brother, Robert W. Newcomb, Ph.D. The fund endows an annual lecture in neuroscience and one or more internships for high-school students at the National Institute of Neurological Disorders and Stroke. Before his death in 2000, at age 44, Dr. Newcomb was passionately devoted to brain research. He first came to NIH as a junior in high school, and thanks to his mentor, Dr. Claude Klee, he became a protein chemist at the age of 17. Dr. Newcomb received his doctorate from the University of Hawaii, and gave up the second year of his Presidential Young Investigator Award to accept his first NIH grant. Dr. Newcomb's association with NIH continued as he later served on NIH study panels. The Newcomb family established this memorial fund because NIH is the most appropriate place to further Dr. Newcomb's work on brain research and the chemical basis of stroke and aging. NIH Neuroscience Seminar Series. |
| Subjects: | Receptors, Glutamate--physiology Synaptic Transmission--physiology |
| Publication Types: | Government Publications |
| Download: | Download
Video How to download a Videocast |
| NLM Classification: | WL 102.8 |
| NLM ID: | 101469028 |
| CIT File ID: | 14336 |
| CIT Live ID: | 6180 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14336 |
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| Description | Runtime | Description | Runtime | |||
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Enhanced Audio Podcast | 1:11:50 |
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Enhanced Video Podcast | 1:11:50 | |