| Title: |
Asymetric development of the brain [electronic resource] : from genes to behavior / Stephen Wilson. |
| Author(s)/Name(s): |
Wilson, S. (Stephen), |
| Publisher: |
[Bethesda, Md. : National Institutes of Health, 2007] |
| Related Names: |
National Institutes of Health (U.S.) |
| Series: |
NIH neuroscience seminar series |
| Language: |
eng |
| Electronic Links: |
http://videocast.nih.gov/launch.asp?13765 |
| MeSH Subjects: |
Brain --growth & development |
|
Behavior --physiology |
|
Signal Transduction --physiology |
|
Lectures |
| Summary: |
(CIT): Altough superficially symmetrical, the vertebrate brain exhibits many functional asymmetries. The neuronal circuitry underlying these functional asymmetries is unknown but is likely to involve many cell groups in diverse regions of the brain. The epithalamus shows conserved asymmetries in many vertebrates and Dr. Wilson has been studying the development of this region of the forebrain in embryonic and larval zebrafish. Dr. Wilson will discuss his group’s progress in studying the signalling pathways that influence the generation of asymmetry and the subsequent laterality of the asymmetry of epithalamic nuclei. For instance, they have found that asymmetries are largely absent in fgf8 mutants and that a key role for Fgf signalling is to mediate the migration of cells that contribute to a left-sided nucleus. They are also studying the morphology and projections of habenular neurons that convey information from the lateralised epithalamic nuclei to the ventral midbrain. Dr Wilson is a member of the Academy of Medical Sciences and the European Molecular Biology Organization and an editor for Development. He received his Bachelor’s Degree from the University of Leicester and his PhD in Neurobiology from the University of London. For his postdoctoral research at the University of Michigan at Ann Arbor, Dr. Wilson studied axonal pathfinding and developmental patterning of the zebrafish brain. As a principal investigator, Dr. Wilson has focused on developmental patterning of the vertebrate forebrain, using the zebrafish model. Research in the Wilson lab has demonstrated that anterior CNS development depends on WNT signal repression by a small population of anterior organizer cells. Dr. Wilson’s group has also identified several neural identity fate choices that depend on the levels of BMP or Sonic Hedgehog signals received. Finally, Dr. Wilson has investigated neuroanatomical left-right asymmetries in the brain, identifying new asymmetries, uncovering a role for Nodal signaling in the choice of neuroanatomical sidedness and linking behavioral changes to L-R reversals in the brain. NIH Neuroscience Seminar Series. |
| Notes: |
Title from screen banner (viewed Aug. 6, 2007). |
|
Streaming video (1 hr., 11 min. : sd., col.). |
|
Mode of access: World Wide Web. |
|
Open-captioned. |
| NLM Unique ID: |
101306071 |
| Other ID Numbers: |
(DNLM)CIT:13765 |
