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Person Details

Superfund Basic Research Program

John Gierthy

University of Albany - SUNY
Empire State Plaza
Wadsworth Center
Albany, NY 12201
Phone: 518-474-8195
Fax:
Email:

Projects

Research Briefs

Publications

2000
  • Arcaro, Kathleen, Yi Yang, Dilip Vakharia, and John Gierthy. 2000. Toxaphene is Antiestrogenic in a Human Breast-Cancer Cell Assay. Journal of Toxicology and Environmental Health. (http://www.tandf.co.uk/journals/titles/152873 94.html) Exit NIEHS Website 59:197-210.
  • Spink, B.C., X. Zhuo, M.M. Hussain, John Gierthy, X. Ding, and David C. Spink. 2000. NADPH- and hydroperoxide-supported 17β-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P450 1B1. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) Exit NIEHS Website 54:96.
  • Spink, David C., B.C. Spink, X. Zhuo, M.M. Hussain, John Gierthy, and X. Ding. 2000. NADPH- and hydroperoxide-supported 17 beta-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P4501B1. Journal of Steroid Biochemistry and Molecular Biology. (http://www.sciencedirect.com/science/journal/ 09600760) Exit NIEHS Website 74(1-2):11-18.
  • Vakharia, Dilip and John Gierthy. 2000. Use of a combined human liver microsome-estrogen receptor assay to assess potential estrogen modulating activity of PCB metabolites. Toxicology Letters. (http://www.sciencedirect.com/science/journal/ 03784274) Exit NIEHS Website 114(1-3):55-65.
1999
  • Arcaro, Kathleen, Patrick O' Keefe, Yi Yang, W. Clayton, and John Gierthy. 1999. Antiestrogenicity of environmental polycyclic aromatic hydrocarbons in human breast cancer cells. Toxicology. (http://www.sciencedirect.com/science/journal/ 0300483X) Exit NIEHS Website 133(2-3):115-127.
  • Arcaro, Kathleen, L. Yi, Richard Seegal, Dilip Vakharia, Yi Yang, David C. Spink, K.O. Brosch, and John Gierthy. 1999. 2,2',6,6'-tetrachlorobiphenyl is estrogenic in vitro and in vivo. Journal of Cellular Biochemistry. (http://www.interscience.wiley.com/jpages/0730 -2312/) Exit NIEHS Website 72(1):94-102.
  • Vakharia, Dilip and John Gierthy. 1999. Rapid assay for estrogen receptor binding to PCB metabolites. Toxicology in Vitro. (http://www.sciencedirect.com/science/journal/ 08872333) Exit NIEHS Website 13(2):275-282.
  • Vakharia, Dilip and John Gierthy. 1999. Rapid screen for ER-binding of human liver microsome-generated PCB-metabolites. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) Exit NIEHS Website 42(1-S):221.
1998
  • Arcaro, Kathleen, Patrick O' Keefe, Yi Yang, and John Gierthy. 1998. Antiestrogenic activity of polycyclic aromatic hydrocarbons. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) Exit NIEHS Website 42(1-S):240.
  • Arcaro, Kathleen, Dilip Vakharia, Yi Yang, and John Gierthy. 1998. Lack of synergy by mixtures of weakly estrogenic hydroxylated polychlorinated biphenyls and pesticides. Environmental Health Perspectives. 106:1041-1046.
  • Seegal, Richard, John Gierthy, Kathleen Arcaro, and K.O. Brosch. 1998. Neurochemical and neuroendocrine effects of non-coplanar and coplanar PCBs. Fundamental and Applied Toxicology. (http://www.sciencedirect.com/science/journal/ 02720590) Exit NIEHS Website 41:49-61.
  • Spink, B.C., M.J. Fasco, John Gierthy, and David C. Spink. 1998. 12-O-Tetradecanolyl-phorbol-13-acetate differentially alters CYP1A1 and CYP1B1 expression in MCF-7 breast cancer cells. Journal of Cellular Biochemistry. (http://www.interscience.wiley.com/jpages/0730 -2312/) Exit NIEHS Website 70:289-296.
1997
  • Arcaro, Kathleen and John Gierthy. 1997. Estrogenic responses of human breast cancer cells to combinations of hydroxylated PCBs, pesticides and 17β-estradiol. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) Exit NIEHS Website 36(1):295.
  • Arcaro, Kathleen, John Gierthy, Yi Yang, Larry W. Robertson, Greg G. Oakley, and Dilip Vakharia. 1997. Position of Hydroxyl Group Influences PCB Estrogenicity and Antiestrogenicity. Organohalogen Compounds. 34:386-390.
  • Gierthy, John, Kathleen Arcaro, and M. Floyd. 1997. Assessment of PCB estrogenicity in a human breast cancer cell line. Chemosphere. (http://www.sciencedirect.com/science/journal/ 00456535) Exit NIEHS Website 34(5-7):1495-1505.
  • Gierthy, John, Yi Yang, Larry W. Robertson, G.G. Oakley, and Kathleen Arcaro. 1997. Position of hydroxyl group influences PCB estrogenicity and antiestrogenicity. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) Exit NIEHS Website 36(1):159.
  • Gierthy, John, Yi Yang, Larry W. Robertson, Greg G. Oakley, and Dilip Vakharia. 1997. Position of hydroxyl group influences PCB estrogenicity and antiestrogenicity. Fundamental and Applied Toxicology. (http://www.sciencedirect.com/science/journal/ 02720590) Exit NIEHS Website 36:159.
  • Spink, David C., J.Q. Cao, John Gierthy, C.L. Hayes, Y. Li, and T.R. Sutter. 1997. Induction of cytochrome P450 1B1 and catechol estrogen metabolism in ACHN renal adenocarcinoma cells. Journal of Steroid Biochemistry and Molecular Biology. (http://www.sciencedirect.com/science/journal/ 09600760) Exit NIEHS Website 62:223-232.
1996
  • Gierthy, John, Richard Seegal, M. Floyd, Kathleen Arcaro, and David C. Spink. 1996. Estrogenic activity of 2,2',6,6'-tetrachlorobiphenyl in MCF-7 human breast cancer cells. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) Exit NIEHS Website 30:225-226.
  • Gierthy, John, B.C. Spink, H.L. Figge, B.T. Pentecost, and David C. Spink. 1996. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate and 17-estradiol on estrogen receptor regulation in MCF-7 human breast cancer cells. Journal of Cellular Biochemistry. (http://www.interscience.wiley.com/jpages/0730 -2312/) Exit NIEHS Website 60:173-184.
  • Seegal, Richard, M.A. Chishti, and John Gierthy. 1996. Uterotropic and neurochemical effects of 2,2',6,6'-tetrachlorobiphenyl in the prepubertal rat. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) Exit NIEHS Website 30:227.
  • Spink, David C., B.C. Spink, C.L. Hayes, J.Q. Cao, John Gierthy, and T.R. Sutter. 1996. TCDD induces catechol estrogen metabolism and CYP1B1 in ACHN human renal adenocarcinoma cells. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) Exit NIEHS Website 30:180.
1995
  • Gierthy, John, Kathleen Arcaro, and M. Floyd. 1995. Assessment and implications of PCB estrogenicity. In: Proceedings of the 15th International Symposium on Chlorinated Dioxins and Related Compounds. pp.419-423.
  • Seegal, Richard and John Gierthy. 1995. Developmental exposure to individual PCB congeners - multiple mechanisms of action. NeuroToxicology. (http://www.neurotoxicology.com/) Exit NIEHS Website 16:753.
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Last Reviewed: 19 May 2008