NINDS Neuroscience Funding Announcements

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Predictive Multiscale Models of the Physiome in Health and Disease (R01)
Release Date: November 5, 2007
Announcement Number: PAR-08-023
Application Receipt Date:
January 14, 2008
May 14, 2008
September 15, 2008
January 14, 2009
May 14, 2009
September 15, 2009
January 14, 2010
May 14, 2010
September 15, 2010    Letter of Intent Date: December 14, 2007
April 14, 2008
August 15, 2008
December 15, 2008
April 14, 2009
August 17, 2009
December 14, 2009
April 14, 2010
August 16, 2010

Funding Contact: Yuan Liu, Ph.D.
Program Area: Office of Translational Research

Brief Description:
The goal of this solicitation is to move the field of biomedical computational modeling forward through the development of more realistic and predictive models of health and disease. NIH recognizes the need for sophisticated, predictive, computational models of development and disease that encompass multiple biological scales. These models may be designed to uncover biological mechanisms or to make predictions about clinical outcome and may draw on a variety of data sources including relevant clinical data. Ultimately the models and the information derived from their use will enable researchers and clinicians to better understand, prevent, diagnose and treat the diseases or aberrations in normal development. Specifically this FOA solicits the development of predictive multiscale models of health and disease states that must include higher scales of the physiome (see definitions below). The specific objectives are to develop multiscale models that are physiologically mechanistic and biomedically relevant, to bring together modeling and biomedical expertise to collaborate on building models, to validate and test models with standard datasets, and to develop models that can be explicitly shared with other modelers.

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