Research Topics

Center for Cancer Research Nanobiology Program (CCRNP)

Nanobiology Structural Biology Sequence Analysis HIV entry Cell Dynamics Microarray DB 2D Proteomics DBs Lab Databases Meeting Notices History NIH & NCI resources Phone & addresses Directions to CCRNP CCRNP home page CCRNP alt. home page

Formerly the Lab. of Experimental and Computational Biology (LECB), Formerly the Lab. of Mathematical Biology (LMMB) Center for Cancer Research, NCI, NIH

Meeting Notices: past and current

• CCRNP Nanobiology Program Thank Tank workshop, June 2, 2006, Frederick

CCRNP Research Topics

Nanobiology

• Robert P. Blumenthal, Ph.D., Program Director
  

Structural Biology

• The Structural Glycobiology Section
• Protein structure comparison and recognition.
• The Protein-Protein Interface
• RNA structure analysis
• Genetic algorithms for RNA structure prediction
• StructureLab Workbench

Sequence Analysis

• Information Theory and Molecular Recognition
• Delila: Software for Information Analysis of Protein and Nucleic-acid Sequences
• NCI MPsrch - massively parallel sequence comparison

HIV entry

• Membrane fusion
• Envelope glycoprotein-CD4-coreceptor complexes

Cell Dynamics

• AIDS
• Cancer

Microarray DB

• MicroArray Explorer analysis software

2D-Gel and Proteomics

• Open2Dprot.sourceforge.net an open source data mining tools for n-dimensional protein expression data
  • Open-source Accession proteomics samples
  • Open-source Seg2Dgel spot segmenter (2D & other images)
  • Open-source CmpSpots spot-matching
  • Open-source Landmark create set of corresponding landmarks
• Open-source Flicker comparison of images across Internet (2D gels & other images)
• 2D-gel image data sets (about 300 samples) are available for public use
• 2DWG meta-database of 2D protein gel images found on the Internet
• GELLAB-II: two-dimensional electrophoretic gel analysis.
• Open-source TMAP ProtPlot Tissue Molecular Anatomy Project / ProtPlot (mapping estimated RNA expression to 2D proteomics space)

Databases available from the Lab

• Glycobiology Resources
• LECB 2D-gel image data sets database available for public use.
• List of databases from Biomedical Image Processing and Database Analysis Group

History

• History of the NCI RTPP (the IPS Real Time Picture Processor)
• Computer Museum Quiz to test your knowledge of computer artifacts

Other NIH, NCI and NCI-Frederick Web sites

• National Institutes of Health
• NIH directory services
• National Cancer Institute
• NCI Campus site (restricted access)
• Center for Cancer Research
• NCI Alliance for Nanotechnology in Cancer

• NCI Calendar

• Main NCI-Frederick Web site
• NCI-Frederick Advanced Biomedical Computing Center (ABCC)
• Frederick NCI/MRMC/NIAID Combined Bioinformatics and Chemoinformatics Forum
• NCI-FCRDC Computer & Statistical Services
• NCI-FCRDC FBSC searchable phone book

• NCI CCR Faculties Index
• NCI Bioinformatics, Biostatistics and Computational Biology Faculty (BBCF)
• NIH-wide Biomedical Computing Interest Group (NIH-BCIG)
• NCI Center for Bioinformatics
• NCI caBIG - Cancer Biomedical Informatics Grid

• National Library of Medicine (NLM)
• NIH Library
• NCI FCRDC Scientific Library
• NIH videocasting (free archive)
• NLM - Medline searching (PubMed)

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