fff: Molecular Flip-Flops Formed by Overlapping Fis Sites

• fff: the paper
  
  
  • BiBTeX reference:

    @article{Hengen.Schneider2003,
    author = "P. N. Hengen
     and I. G. Lyakhov
     and L. E. Stewart
     and T. D. Schneider",
    title = "Molecular Flip-Flops Formed by Overlapping {Fis} Sites",
    journal = "Nucleic Acids Res.",
    volume = "31, No. 22",
    pages = "6663-6673",
    year = "2003"}
    

  • Offical versions at Nucleic Acids Research:

    • Abstract: Molecular Flip-Flops Formed by Overlapping Fis Sites

    • Full Text: Molecular Flip-Flops Formed by Overlapping Fis Sites

  • My preprints:

    • Molecular Flip-Flops Formed by Overlapping Fis Sites
      PostScript version

    • Molecular Flip-Flops Formed by Overlapping Fis Sites
      PDF version

    

  • Proposed cover figure (not used)

    
    
  

• fff: the patent: Molecular Computing Elements: Gates and Flip-Flops

• fff: the PostDoc position

• See also the previous paper: Information analysis of Fis binding sites

If you need background information about information theory you can explore my web site. You may find these two resources particularly useful:

• Information Theory Primer, With an Appendix on Logarithms
• A Glossary for Molecular Information Theory and the Delila System.
  A good starting point would be the definition of a bit.

Tom Schneider

3 Dimensional Models

• monomer Fis bound to DNA
• two Fis molecules bound to DNA with 7 base pair spacing
• two Fis molecules bound to DNA with 11 base pair spacing

Related References

• Hasty J, McMillen D, Collins JJ. Engineered gene circuits. Nature. 2002 Nov 14;420(6912):224-30. Review. PubMed PMID: 12432407
• Isaacs FJ, Hasty J, Cantor CR, Collins JJ. Prediction and measurement of an autoregulatory genetic module. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7714-9. Epub 2003 Jun 13. PubMed PMID: 12808135

Schneider Lab
origin: 2003 October 14
updated: 2007 Apr 27