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Model Characteristics - Model:
TH-MYCN transgenic model for neuroblastoma
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| Model Descriptor |
TH-MYCN transgenic model for neuroblastoma
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| Official Nomenclature |
129X1/SvJ-Tg(TH-MYCN)41Waw
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| Genotype |
TH-MYCN
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| Species |
Mouse (Mus musculus)
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| Strain |
129
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| Is This a Tool Strain? |
No
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Developmental Stage
(applies only to Zebrafish) |
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| Experimental Design |
MYCN is amplified in childhood neuroblastoma. We have over-expressed this gene in the peripheral neural crest of transgenic animals to create a mouse model for this disease.
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| Phenotype |
Animals develop tumor of the peripheral neural crest in abdominal and thoraci paraspinous locations.
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| Website for add. info |
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| Breeding Notes |
129/SvJ animals are highly penetrant. Breeding is easier by mating tg males with wt females
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| Sex Distribution of the Phenotype |
Both Sexes
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| Submitted by |
Weiss, William
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| Principal Investigator / Lab |
Weiss, William
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| Comment |
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| Model Availability: This model is available from |
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