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 Technology Information 
A TRANSGENIC MURINE MODEL FOR XSCID
00/00/00
E-079-1993/0
Nonexclusive license
Description of Invention:
The invention provides a method of diagnosing X-linked severe combined immunodeficiency (XSCID) in males or determining whether females are carriers. This method is based upon the presence of either a mutated or truncated IL-2Rg gene. The invention also discloses a method of treating XSCID as well as a method for monitoring the therapy. Lastly, the invention provides a promoter which regulates the expression of IL-2Rg, a vector comprising a DNA molecule operably linked to the promoter, a cell host that has been transformed with the vector, and a transgenic mouse comprising the promoter or a mutant IL-2Rg.

Potential Area of Application:
diagnosing XSCID-
identifying a carrier-
treating XSCID-
monitoring effectiveness of therapy for XSCID-
research reagent.

Main Advantage of Invention:
diagnostic test is only way of definitively diagnosing XSCID-
process for diagnosis is completely developed.


Inventors:
Warren J. Leonard (NHLBI),
Masayuki Noguchi (NHLBI),
Wesley McBride (NCI).

Patent Status:
USSN 08/031,143 entitled "Methods for Diagnosis of XSCID and Kits Thereof" filed 12 Mar 1993, issued as U.S. Patent No. 5,518,880 on 21 May 1996. USSN 08/424,224 entitled "A Transgenic Murine Model for XSCID" filed 19 Apr 1995, issued as U.S. Patent No. 5,912,173 on 15 Jun 1999, No foreign rights.



Portfolios:
Internal Medicine-Diagnostics-Anti-Inflammatory (including Autoimmune)-Therapeutics-Anti-Inflammatory.

For Additional Information Please Contact:
Thomas P. Clouse J.D.,
NIH Office of Technology Transfer,
6011 Executive Blvd, Suite 325,
Rockville, MD 20852-3804,
Phone: (301)435-4076,
Email: clousetp@mail.nih.gov,
Fax: (301)402-0220.


XSCID, X-Linked Severe Combined Immunodeficiency, IL-2 Receptor gamma
 Links Listing 
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Patent Link U.S. Patent No. 5,518,880 More Information
Patent Link U.S. Patent No. 5,912,173 More Information
Publication Link Relevant Publication More Information
Publication Link Relevant Publication More Information
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