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 Technology Information 
MAMMALIAN GUANINE NUCLEOTIDE BINDING PROTEIN WITH AN ADP-RYBOSYLATION FACTOR DOMAIN
00/00/00
E-037-1993/0
Unlicensed
Description of Invention:

ADP-ribosylation factors (ARFs) constitute one family of the -20-kDa guanine nucleotide-binding ras superfamily. ARFs regulate secretory, endocytic, exocytic, and nuclear fusion events and activate phospholipase D and cholera toxin. ARD1 is a 64-kDa protein containing an ARF domain at its carboxy terminus. This invention includes a cell line transfected with an expression vector containing either rat or human ARD-1 DNA and an immunoassay kit for detecting ARD proteins in samples.

Inventors: J Moss, K Mishima, MS Nightingale, and M Tsuchiya (NHLBI).

Patent Status:

Serial No. 08/312,648 filed 27 Sep 1994.
U.S. Patent 5,514,600 issued 07 May 1996, DIV of U.S. Patent 5,386,021 issued 31 Jan 1995 .

Portfolios:

Infectious Diseases -Therapeutics.

For Additional Information Please Contact:

George Pipia Ph.D.,
Office of Technology Transfer
6011 Executive Blvd, Suite 325,
Rockville, MD 20852-3804
Phone: (301) 435-5560
Email: pipiag@mail.nih.gov
Fax: (301) 402-0220


Cholera Toxin, Adenylyl Cyclase, Ras-Like Protein, ARD1, ARF
 Links Listing 
Name Description Opens a New Browser Window
Inventor's URL Link to Dr. Joel Moss' web page More Information
Patent Link Patent No. 5,386,021 More Information
Patent Link Patent No. 5,514,600 More Information
Publication Link Relevant Publication More Information
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