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| Strain
Number: |
01XP1 |
| Common
Strain Name: |
XPV knockout |
| Strain
Nomenclature: |
B6;129-Polhtm1Rak |
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| Release
Category (Required for MTA form):
C,D
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| Animal Health Report in PDF Format |
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| Strain
Description: |
The DNA polymerase eta gene (Polh, XPV) was inactivated by Cre-loxP mediated germline deletion of exon 4. Homozygous mice are fertile. Skin tumors can be induced 2~3-month after exposure to ultraviolet (UV) light with 100% frequency. No abnormal B-cell physiology has been observed. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
polymerase (DNA directed), eta (RAD 30 related)
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Gene
Symbol: |
Polh
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
B6;129 |
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Approx.
Generation: |
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Organ
Site : |
Skin |
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Cryopreservation Mating Scheme: |
Wild-type C57BL/6NCr females x homozygous males
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| Genotyping Information: |
Protocol 1: Allele: Polh
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| Donating
Investigator: |
Dr. Raju Kucherlapati |
| Key
Reference: |
Qingcong Lin, Alan B. Clark, Scott D. McCulloch, Tao Yuan, Roderick T. Bronson, Thomas A. Kunkel, and Raju Kucherlapati. Increased Susceptibility to UV-Induced Skin Carcinogenesis in Polymerase eta-deficient Mice. Cancer Res. 66, 87-94, 2006. PMID:16397220.
[PubMED
Abstract]
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| Sponsoring Institute: |
CA 084301 (NCI), ES11040 (NIEHS) |
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