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| Strain Number: | 01XN8 | ||
| Common Strain Name: | 76 T2/Onc (Sleeping Beauty) | ||
| Strain Nomenclature: | FVB-TgTn(sb-T2/Onc)76Dla | ||
| Release Category (Required for MTA form): C | |||
| Animal Health Report in PDF Format | |||
| Strain Description: | 76 T2/Onc mice carry Sleeping Beauty transposon concatemers on chromosome 1. Together with a strain expressing the Sleeping Beauty transposase, CAGGS-SB10 (MMHCC strain 01XN7), these mice can be used for unbiased, forward genetic screens for cancer genes in vivo. | ||
| Mutation Information | |||
| Mutation Type: | Transgenic | ||
| Gene Name: | |||
| Gene Symbol: | |||
| Transgene Name: | sleeping beauty transposon (mouse) | ||
| Transgene Symbol: | sb | ||
| Promoter Name: | |||
| Promoter Symbol: | |||
| Current Genetic Background: | FVB/NCr | ||
| Approx. Generation: | 5 | ||
| Organ Site : | various | ||
| Husbandry: | Breeder pairs are supplied as a hemizygote (male or female) x wild-type FVB mate (male or female). Average litter size is 6-8. | ||
| Genotyping Information: | Protocol 1: Allele: TgTn(sb-T2/Onc)76Dla | ||
| Donating Investigator: | David Largaespada | ||
| Key Reference: | Collier LA, Carlson CM, Ravimohan S, Dupuy AJ, Largaespada DA. Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse. Nature 436, 272-276, 2005. PMID: 16015333. [PubMED Abstract] | ||
| Sponsoring Institute: | NIH-NCI, U01 (CA84221, Years 6-10), 2/15/03 - 3/31/09, NIH-NIDA, R01 (DA014764), 2/15/03 - 11/30/05 | ||
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