| |
|
| |
|
| Strain
Number: |
01XM4 |
| Common
Strain Name: |
Nf1 flox |
| Strain
Nomenclature: |
B6;129-Nf1tm1Par |
| |
|
|
| Release
Category (Required for MTA form):
B,D
|
|
| Animal Health Report in PDF Format |
|
|
|
|
| |
|
|
|
| Strain
Description: |
These mice carry a floxed allele of Nf1 with LoxP sites in introns 30 and 32. The animals are phenotypically normal; homozygous mice are viable. This is a useful strain for the study of neurofibromatosis and other cancers associated with loss of Nf1 function. |
| |
|
|
|
| Mutation
Information |
|
| |
Mutation
Type: |
Targeted |
| |
Gene
Name: |
Neurofibromatosis 1
|
| |
Gene
Symbol: |
Nf1
|
| |
Transgene
Name: |
|
| |
Transgene
Symbol: |
|
| |
Promoter
Name: |
|
| |
Promoter
Symbol: |
|
| |
Current
Genetic Background: |
B6;129 |
| |
Approx.
Generation: |
|
| |
Organ
Site : |
Brain, skin |
| |
|
|
|
|
Cryopreservation Mating Scheme: |
C57BL/6 females x heterozygous males |
|
| Genotyping Information: |
Protocol 1: Allele: Nf1
|
| |
|
|
|
| Donating
Investigator: |
Dr. Luis Parada |
| Key
Reference: |
Zhu Y; Romero MI; Ghosh P; Ye Z; Charnay P; Rushing EJ; Marth JD; Parada LF. Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev 15, 859-876, 2001.
PMID: 11297510.
[PubMED
Abstract]
|
| |
|
|
|
| |
|
|
|
|
