| |
|
| |
|
| Strain
Number: |
01XM2 |
| Common
Strain Name: |
p53 LSL R172H |
| Strain
Nomenclature: |
129S4-Trp53tm2Tyj |
| |
|
|
| Release
Category (Required for MTA form):
B,D
|
|
| Animal Health Report in PDF Format |
|
|
|
|
| |
|
|
|
| Strain
Description: |
These mice contain a point-mutant allele of Trp53 that can be activated by Cre-mediated recombination. The conditional allele, containing LoxP sites and a transcriptional/translational STOP sequence, is functionally equivalent to a null mutation. |
| |
|
|
|
| Mutation
Information |
|
| |
Mutation
Type: |
Targeted |
| |
Gene
Name: |
Transformation related protein 53
|
| |
Gene
Symbol: |
Trp53
|
| |
Transgene
Name: |
|
| |
Transgene
Symbol: |
|
| |
Promoter
Name: |
|
| |
Promoter
Symbol: |
|
| |
Current
Genetic Background: |
129S4/SvJae |
| |
Approx.
Generation: |
8 |
| |
Organ
Site : |
|
| |
|
|
|
|
Husbandry: |
Heterozygous breeder pairs are provided. Homozygotes are viable and fertile but have decreased fertility and die young. Easiest to maintain as heterozygotes. |
| Genotyping Information: |
Protocol 1: Allele: Trp53
|
| |
|
|
|
| Donating
Investigator: |
Dr. Tyler Jacks |
| Key
Reference: |
Olive KP, Tuveson DA, Ruhe ZC, Yin B, Willis NA, Bronson RT, Crowley D, Jacks T. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell. 2004 Dec 17;119(6):847-60.
PMID: 15607980
[PubMED
Abstract]
|
| |
|
|
|
| |
|
|
|
|
