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| Strain
Number: |
01XL9 |
| Common
Strain Name: |
p53 R172H |
| Strain
Nomenclature: |
129S4-Trp53tm2.1Tyj |
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| Release
Category (Required for MTA form):
B,D
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| Animal Health Report in PDF Format |
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| Strain
Description: |
These mice express point-mutant p53 under control of the endogenous Trp53 promoter. Heterozygous mice have an increased tumor burden relative to Trp53+/- mice but similar survival curves. The animals show a broad tumor spectrum with an increased frequency of carcinomas, osteosarcomas, hemangiosarcomas, and lymphoblastic lymphomas. Osteosarcomas are more frequently metastatic. An improved model for Li-Fraumeni Syndrome. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Transformation related protein 53
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Gene
Symbol: |
Trp53
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
129S4/SvJae |
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Approx.
Generation: |
6 |
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Organ
Site : |
multiple |
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Cryopreservation Mating Scheme: |
129S4 females x heterozygous males |
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| Genotyping Information: |
Protocol 1: Allele: Trp53
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| Donating
Investigator: |
Dr. Tyler Jacks |
| Key
Reference: |
Olive KP, Tuveson DA, Ruhe ZC, Yin B, Willis NA, Bronson RT, Crowley D, Jacks T. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell. 2004 Dec 17;119(6):847-60.
PMID: 15607980
[PubMED
Abstract]
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