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| Strain
Number: |
01XL5 |
| Common
Strain Name: |
Pdx-1-cre |
| Strain
Nomenclature: |
B6.FVB-Tg(Ipf1-cre)1Tuv |
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| Release
Category (Required for MTA form):
B,D
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| Animal Health Report in PDF Format |
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| Strain
Description: |
Pdx-1-Cre mice exhibit a stochastic pattern of high-level Cre expression in the pancreas (Hingorani et al., 2003). When combined with Tyler Jacks' latent activatable K-ras allele, LSL-KrasG12D (Kras2, MMHCC strain code 01XJ6), Pdx-1-Cre causes ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs). Some of these lesions progress to invasive and metastatic adenocarcinomas. |
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| Mutation
Information |
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Mutation
Type: |
Transgenic |
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Gene
Name: |
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Gene
Symbol: |
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Transgene
Name: |
Cre recombinase
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Transgene
Symbol: |
Cre
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Promoter
Name: |
Insulin promoter factor 1 (Ipf1, Pdx1) |
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Promoter
Symbol: |
Ipf1, Pdx1 |
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Current
Genetic Background: |
B6.FVB |
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Approx.
Generation: |
5 |
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Organ
Site : |
Pancreas |
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Husbandry: |
Breeder pairs are supplied as a hemizygote (male or female) and a wildtype C57BL/6 mate (male or female). Average litter size is 7. |
| Genotyping Information: |
Protocol 1: Allele: Tg(Ipf1-cre)1Tuv
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| Donating
Investigator: |
Andrew M. Lowy |
| Key
Reference: |
Hingorani SR; Petricoin EF; Maitra A; Rajapakse V; King C; Jacobetz MA; Ross S; Conrads TP; Veenstra TD; Hitt BA; Kawaguchi Y; Johann D; Liotta LA; Crawford HC; Putt ME; Jacks T; Wright CV; Hruban RH; Lowy AM; Tuveson DA (2003). Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4, 437-450. PMID: 14706336
[PubMED
Abstract]
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