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| Strain Number: | 01XL4 | ||
| Common Strain Name: | PB-FGF8b-line 3 | ||
| Strain Nomenclature: | B6D2F2-Tg(AAR2/Pbsn-FGF8)3Prb | ||
| Release Category (Required for MTA form): B,D | |||
| Animal Health Report in PDF Format | |||
| Strain Description: | The mice spontaneously developed prostatic epithelial hyperplasia by 2-3 months of age. The disease progressed to low-grade PIN by 5-7 months, and high-grade PIN (15-17 months), in a markedly stochastic pattern reminiscent of the slow progression of prostatic disease in humans. Within the two-year observation period, stromal hypercellularity and chronic inflammation were observed but no invasive cancer was found. This mouse model indicates that overexpression of Fgf8b is sufficient to drive proliferation in the prostatic epithelium. | ||
| Mutation Information | |||
| Mutation Type: | Transgenic | ||
| Gene Name: | |||
| Gene Symbol: | |||
| Transgene Name: | Fgf8b | ||
| Transgene Symbol: | Fgf8b | ||
| Promoter Name: | ARR2PB rat (composite) | ||
| Promoter Symbol: | ARR2PB | ||
| Current Genetic Background: | (C57BL/6 x DBA2) F2 | ||
| Approx. Generation: | 5 | ||
| Organ Site : | Prostate | ||
| Cryopreservation Mating Scheme: | Heterozygous males x wild-type females (B6D2F1/Cr) | ||
| Genotyping Information: | There are currently no protocols available for this strain. | ||
| Donating Investigator: | Dr. Pradip Roy-Burman | ||
| Key Reference: | Song Z, Wu X, Powell WC, Cardiff RD, Cohen MB, Tin RT, Matusik RJ, Miller GJ, Roy-Burman P. Fibroblast growth factor 8 isoform B overexpression in prostate epithelium: a new mouse model for prostatic intraepithelial neoplasia. Cancer Res. 2002 Sep 1;62(17):5096-105. PMID: 12208767 [PubMED Abstract] | ||
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