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| Strain
Number: |
01XK6 |
| Common
Strain Name: |
E2f3 |
| Strain
Nomenclature: |
B6;129S-E2f3tm1Lees |
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| Release
Category (Required for MTA form):
B
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| Animal Health Report in PDF Format |
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| Strain
Description: |
Phenotype not fully penetrant on mixed background. Surviving E2F3 null adults die from dilated cardiomyopathy (similar to the human disease) and are smaller than littermates. Embryos dying in utero have defects in heart development. On a pure background all E2F3 null embryos die in utero. Mouse embryo fibroblasts lacking E2F3 have defects in entry into the cell cycle and hence proliferation. Proliferation defects in the embryo are also apparent. E2F3 is a key regulator of proliferation and loss of E2F3 suppresses tumorigenesis in mice heterozygous for a mutation in the tumor suppressor gene pRb. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
E2f transcription factor 3
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Gene
Symbol: |
E2f3
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
B6; 129S2/SvPas x 129S6/SvEv |
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Approx.
Generation: |
4 |
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Organ
Site : |
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Cryopreservation Mating Scheme: |
Heterozygous males x C57BL/6NCr females |
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| Genotyping Information: |
Protocol 1: Allele: E2f3
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| Donating
Investigator: |
Dr. Jacqueline Lees |
| Key
Reference: |
Humbert P O, Verona R, Trimarchi JM, Rogers C, Dandapani S, and Lees J. 2000 E2f3 is critical for normal cellular proliferation. Genes and Development 14(6):690-703.
PMID: 10733529
[PubMED
Abstract]
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