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| Strain Number: | 01XJ8 | ||
| Common Strain Name: | HPV16-E6 | ||
| Strain Nomenclature: | FVB-Tg(KRT14-HPV16E6)5737Plam | ||
| Release Category (Required for MTA form): B,D | |||
| Animal Health Report in PDF Format | |||
| Strain Description: | This strain carries 15 copies of the K14-HPV16 E6 transgene. Hemizygous animals develop epithelial hyperplasia (wrinkled skin visible at 12 days of age), skin tumors, and cervical tumors (when crossed to K14E7 mice treated with estrogen). Skin tumors arise late in 14% of the mice (at 15 months of age, first onset at 6 months). Lesions are malignant, grade I-III epidermoid carcinomas. Cataracts are also apparent by weaning. | ||
| Mutation Information | |||
| Mutation Type: | Transgenic | ||
| Gene Name: | |||
| Gene Symbol: | |||
| Transgene Name: | human papillomavirus type 16 | ||
| Transgene Symbol: | HPV16 | ||
| Promoter Name: | human keratin | ||
| Promoter Symbol: | hK14 | ||
| Current Genetic Background: | FVB | ||
| Approx. Generation: | |||
| Organ Site : | Skin | ||
| Cryopreservation Mating Scheme: | Wild-type females (FVB/N) x homozygous males | ||
| Genotyping Information: | Protocol 1: Allele: Tg(hK14-HPV16-E6)5737Plam | ||
| Donating Investigator: | Dr. Paul Lambert | ||
| Key Reference: | Shiyu S, Pitot HC, and Lambert PF. 1999. The Human Papillomavirus Type 16 E6 Gene Alone Is Sufficient To Induce Carcinomas in Transgenic Animals. J. Virol. 73:5887-5893 PMID: 10364340 [PubMED Abstract] | ||
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