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| Strain
Number: |
01XJ4 |
| Common
Strain Name: |
iMycEu |
| Strain
Nomenclature: |
STOCK Ightm1Janz |
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| Release
Category (Required for MTA form):
B,D
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| Animal Health Report in PDF Format |
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| Strain
Description: |
Mouse c-Myc was inserted into the mouse immunoglobulin heavy-chain locus, Igh, just 5' of the intronic enhancer, Eó, to mimic the MYC-activating chromosomal t(8;14)(q24;q32) translocation most commonly observed in human endemic Burkitt lymphoma. Heterozygous iMycEó mice develop a spectrum of B-cell tumors, including Burkitt-like lymphoblastic B-cell lymphoma, diffuse large B-cell lymphoma, and plasmacytoma. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Immunoglobulin heavy chain complex - Myelocytomatosis oncogene (inserted)
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Gene
Symbol: |
Igh-Myc
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
STOCK |
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Approx.
Generation: |
12 |
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Organ
Site : |
Hematopoetic |
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Cryopreservation Mating Scheme: |
C57BL/6 females x heterozygous males |
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| Genotyping Information: |
Protocol 1: Allele: Igh
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| Donating
Investigator: |
Dr. Siegfried Janz |
| Key
Reference: |
Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. Park SS, Kim JS, Tessarollo L, Owens JD, Peng L, Han SS, Tae Chung S, Torrey TA, Cheung WC, Polakiewicz RD, McNeil N, Ried T, Mushinski JF, Morse HC 3rd, Janz S. Cancer Res. 2005 Feb 15;65(4):1306-15. PMID 15735016
[PubMED
Abstract]
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