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| Strain
Number: |
01XJ2 |
| Common
Strain Name: |
p19(Arf) null (FVB) |
| Strain
Nomenclature: |
FVB.129-Cdkn2atm1Nesh |
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| Release
Category (Required for MTA form):
A
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| Animal Health Report in PDF Format |
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| Strain
Description: |
This is a KO of exon 1 beta of p19Arf (the p19Arf-specific KO), an important tumor suppressor gene. This allele is similar to a p19Arf KO made by the Sherr lab (Cdkn2atm1Cjs), except this KO deletes the selectable marker (Neo). These animals may be slightly less tumor prone than the Sherr KO, and do not overexpress p16Ink4a (the other product of the Ink4a/Arf locus). These animals were made in a manner identical to the p16Ink4a-specific KO available from the MMHCC, and serve as useful comparison to that strain. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Cyclin-dependent kinase inhibitor 2A
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Gene
Symbol: |
Cdkn2a
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
FVB.129 |
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Approx.
Generation: |
7 |
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Organ
Site : |
All |
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Cryopreservation Mating Scheme: |
Heterozygous male x wild-type female (FVB/N)
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| Genotyping Information: |
Protocol 1: Allele: Cdkn2a
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| Donating
Investigator: |
Dr. Norman Sharpless |
| Key
Reference: |
Sharpless NE, Ramsey MR, Balasubramanian P, Castrillon DH, DePinho RA (2004). The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis. Oncogene 23, 379-385. PMID: 14724566
[PubMED
Abstract]
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| Related
References: |
Kannan K, Sharpless NE, Xu J, O'Hagan RC, Bosenberg M, Chin L. Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model.
Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1221-5. Epub 2003 Jan 21.
PMID: 12538879
[PubMED
Abstract] |
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