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| Strain
Number: |
01XH9 |
| Common
Strain Name: |
Mdm-2flox |
| Strain
Nomenclature: |
129(Cg)-Mdm2tm1.2Mep |
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| Release
Category (Required for MTA form):
B,D
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| Animal Health Report in PDF Format |
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| Strain
Description: |
This strain carries a conditional allele of mdm2 that functions as a wild type allele prior to excision by the Cre recombinase. Cre-mediated deletion of exons 7-9 in vivo has been shown. This strain is useful for studying functions of Mdm2, an essential inhibitor of p53. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Murine double minute 2
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Gene
Symbol: |
Mdm2
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
129.Cg |
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Approx.
Generation: |
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Organ
Site : |
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Cryopreservation Mating Scheme: |
Wild-type (129S1/SvImJ/Cr) females x homozygous males |
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| Genotyping Information: |
Protocol 1: Allele: Mdm2
Protocol 2: Allele: Mdm2
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| Donating
Investigator: |
Dr. Mary Ellen Perry |
| Key
Reference: |
Mendrysa SM, McElwee MK, Michalowski J, O'Leary KA, Young KM, and Perry ME. 2003 mdm2 Is Critical for Inhibition of p53 during Lymphopoiesis and the Response to Ionizing Irradiation. Molecular and Cellular Biology 23:462-472.
PMID: 12509446
[PubMED
Abstract]
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