|
|
|
| Strain Number: | 01XH8 | ||
| Common Strain Name: | Tsc1 | ||
| Strain Nomenclature: | B6;129S4-Tsc1tm1.1Djk | ||
| Release Category (Required for MTA form): B | |||
| Animal Health Report in PDF Format | |||
| Strain Description: | Tsc1(-/+) heterozygotes develop kidney cystadenomas and liver hemangiomas. Tsc1 null mutants die at mid gestation. | ||
| Mutation Information | |||
| Mutation Type: | Targeted | ||
| Gene Name: | Tuberois sclerosis | ||
| Gene Symbol: | Tsc1 | ||
| Transgene Name: | |||
| Transgene Symbol: | |||
| Promoter Name: | |||
| Promoter Symbol: | |||
| Current Genetic Background: | B6;129S4 | ||
| Approx. Generation: | |||
| Organ Site : | |||
| Cryopreservation Mating Scheme: | C57BL/6 females x heterozygous males | ||
| Genotyping Information: |
Protocol 1: Allele: Tsc1 |
||
| Donating Investigator: | Dr. David Kwiatkowski | ||
| Key Reference: | Kwiatkowski, D.J., Zang, H., Bandura, JL, Heiberger, K.M, Glogauer, M., Hashemite, N., Onda, H. 2002 A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet 11:525-534 PMID: 11875047 [PubMED Abstract] | ||
 |
 |
 |