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| Strain
Number: |
01XH3 |
| Common
Strain Name: |
PTEN |
| Strain
Nomenclature: |
B6.129-Ptentm1Rps |
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| Release
Category (Required for MTA form):
C
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| Animal Health Report in PDF Format |
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| Strain
Description: |
Homozygous embryos do not survive past embryonic day 6.5. Heterozygous mice develop tumors in a variety of organs. These include tumors of the uterus, prostate, thyroid, colon, and adrenal medulla. Pten (+/-) mice are predisposed to intestinal polyposis. Tumor phenotypes vary depending upon mouse genetic background.
Heterozygous females are fertile only for a brief period of 2-3 months due to uterine neoplasia. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
phosphatase and tensin homolog
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Gene
Symbol: |
PTEN
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
B6.129 |
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Approx.
Generation: |
10 |
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Organ
Site : |
Multiple |
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Husbandry: |
Breeder pairs are supplied as a heterozygous male with a wildtype C57BL/6 female. The main breeding problem is that +/- females are fertile for a brief period between 2 to 3 months. This is because they develop a uterine neoplasia. To get best results, the donating lab recommends mating male +/- with wild type (+/+) females from the colony. |
| Genotyping Information: |
Protocol 1: Allele: Pten
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| Donating
Investigator: |
Dr. Ramon Parsons |
| Key
Reference: |
Podsypanina K, Ellenson LH, Nemes A, Gu J, Tamura M, Yamada KM, Cardo CC, Catoretti G, Fisher PE, and Parsons R. 1999. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci USA 96: 1563-1568.
PMID: 9990064
[PubMED
Abstract]
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