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| Strain
Number: |
01XH2 |
| Common
Strain Name: |
Mdm-2puro |
| Strain
Nomenclature: |
129-Mdm2tm1Mep |
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| Release
Category (Required for MTA form):
B,D
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| Animal Health Report in PDF Format |
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| Strain
Description: |
The mdm2puro allele is a hypomorphic and conditional allele that can be converted to either a fully functional conditional allele or a null allele by the Cre recombinase. Mice expressing mdm2puro (Tac125) allele and one known null allele of mdm2 have reduced levels of expression of the oncogene mdm2 and, as a consequence, are small, radiosensitive and lymphopenic. All phenotypes are dependent on p53. Although the transcriptional activation function of p53 is increased in many tissues, spontaneous, p53-dependent apoptosis occurs in only a subset of these tissues. These mice will be valuable for identifying the regulatory steps that control p53 function in tissues. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Murine double minute 2
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Gene
Symbol: |
Mdm2
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
129/SvEv |
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Approx.
Generation: |
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Organ
Site : |
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Cryopreservation Mating Scheme: |
Wild-type (129S1/SvImJ/Cr) females x homozgyous males |
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| Genotyping Information: |
Protocol 1: Allele: Mdm2
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| Donating
Investigator: |
Dr. Mary Ellen Perry |
| Key
Reference: |
Mendrysa SM, McElwee MK, Michalowski J, O'Leary KA, Young KM, and Perry ME. 2003 mdm2 Is Critical for Inhibition of p53 during Lymphopoiesis and the Response to Ionizing Irradiation. Molecular and Cellular Biology 23:462-472.
PMID: 12509446
[PubMED
Abstract]
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