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| Strain
Number: |
01XG1 |
| Common
Strain Name: |
Nkx3.1 null |
| Strain
Nomenclature: |
FVB.129-Nkx3-1tm1Mms |
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| Release
Category (Required for MTA form):
B
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| Animal Health Report in PDF Format |
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| Strain
Description: |
This strain carries a targeted null mutation in the Nkx3-1 (Nkx3.1) gene, which appears to function as a tumor suppressor gene in the prostate. Homozygous males display histological defects resembling prostatic intraepithelial neoplasia (PIN) in humans. These mice appear to provide an accurate model for the early stages of prostate carcinogenesis. PIN-like lesions are less frequent on a 129/SvImJ background than on C57BL/6J or FVB/N. Heterozygous mice display a similar, less severe, phenotype, indicating haploinsufficiency. There is no reported female phenotype. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
NK-3 transcription factor, locus 1 (Drosophilia)
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Gene
Symbol: |
Nkx3-1
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
FVB.129 |
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Approx.
Generation: |
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Organ
Site : |
Prostate |
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Cryopreservation Mating Scheme: |
FVB/N females x homozygous males |
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| Genotyping Information: |
Protocol 1: Allele: Nkx3.1
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| Donating
Investigator: |
Dr. Cory Abate-Shen |
| Key
Reference: |
Kim MJ, Bhatia-Gaur R, Banach-Petrosky WA, Desai N, Wang Y, Hayward SW, Cunha GR, Cardiff RD, Shen MM, Abate-Shen C. 2002 Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis. Cancer Res. 62:2999-3004
PMID: 12036903
[PubMED
Abstract]
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