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| Strain
Number: |
01XF8 |
| Common
Strain Name: |
PML null |
| Strain
Nomenclature: |
129/Sv-Pmltm1Ppp |
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| Release
Category (Required for MTA form):
B
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| Animal Health Report in PDF Format |
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| Strain
Description: |
Mice homozygous for this mutation (-/-) have a reduced number of circulating granulocytes, basophils and eosinophils, and a reduction in the number of circulating myeloid cells. There is no increase in spontaneous tumors over wildtype (+/+) littermates during the first year of life, but -/- mice develop more tumors than +/+ mice when exposed to dimethylbenzanthracene (DMBA) followed by 12-O-tetradecanoylphorbol-13-acetate (TPA). Retinoic acid has little growth suppressive activity on embryonic fibroblasts (MEFs) derived from -/- mice. MEFs derived from -/- mice grow faster than those derived from +/+ mice and are markedly better at forming colonies. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
promyelocytic leukemia
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Gene
Symbol: |
PML
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
129/Sv |
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Approx.
Generation: |
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Organ
Site : |
Hematopoietic |
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Cryopreservation Mating Scheme: |
Wild-type females (129S1/SvlmJ/Cr) x homozgyous males |
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| Genotyping Information: |
Protocol 1: Allele: Pml
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| Donating
Investigator: |
Dr. Pier Paolo Pandolfi |
| Key
Reference: |
Wang ZG, Delva L, Gaboli M, Rivi R, Giorgio M, Cordon-Cardo C, Grosveld F, Pandolfi PP.
Role of PML in cell growth and the retinoic acid pathway. Science. 1998 279:1547-51
PMID: 9488655
[PubMED
Abstract]
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| Related
References: |
Wang ZG, Ruggero D, Ronchetti S, Zhong S, Gaboli M, Rivi R, Pandolfi PP. PML is essential for multiple apoptotic pathways. Nat Genet. 1998 20:266-72
PMID: 9806545 [PubMED
Abstract] |
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