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| Strain Number: | 01XEA | ||
| Common Strain Name: | EGFR-L858R | ||
| Strain Nomenclature: | B6;CBA-Tg(tetO-EGFR*L858R)56Hev | ||
| Release Category (Required for MTA form): B | |||
| Animal Health Report in PDF Format | |||
| Strain Description: | These mice need to be crossed to an appropriate rtTA strain for inducible expression of the EGFR L858R allele. EGFR L858R has been found in lung tumors from patients who respond to the tyrosine kinase inhibitors erlotinib and gefitinib. In double transgenic mice, expression of this mutant in the lung gave rise to lung tumors that required continued EGFR Del L747-S752 expression for survival and regressed when treated with erlotinib (Politi et al., 2006). | ||
| Mutation Information | |||
| Mutation Type: | Transgenic | ||
| Gene Name: | |||
| Gene Symbol: | |||
| Transgene Name: | EGFR-L858R point mutation | ||
| Transgene Symbol: | EGFR-L858R | ||
| Promoter Name: | Tet-inducible promotor | ||
| Promoter Symbol: | tetO | ||
| Current Genetic Background: | B6;CBA | ||
| Approx. Generation: | |||
| Organ Site : | various, lung | ||
| Husbandry: | Breeder pairs are supplied as a hemizygote (male or female) and wildtype C57BL/6 (male or female) mate. Average litter size is 10. | ||
| Genotyping Information: | Protocol 1: Allele: Tg(tetO-EGFR*L858)56Hev | ||
| Donating Investigator: | Dr. Katerina Politi | ||
| Key Reference: | Politi K, Zakowski MF, Fan PD, Schonfeld EA, Pao W, Varmus HE. Lung adenocarcinomas induced in mice by mutant EGFR receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. Genes & Development 20, 1496-1510, 2006. PMID:16705038 [PubMED Abstract] | ||
| Sponsoring Institute: | Small Animal Imaging Resource Program [SAIRP] grant ]NIH R24CA83084] to Jason Koutcher, American Cancer Society- Post-doctoral Fellowship (PF-05-078-01-MGO) to Katerina Politi, Labrecque Foundation, NCI (K08-CA097980) to William Pao, Carmel Hill Fund, Joan's Legacy | ||
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