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| Strain
Number: |
01XD3 |
| Common
Strain Name: |
s100B-v-erbB (Ink4a-Arf +/-) |
| Strain
Nomenclature: |
B6.Cg-Tg(S100b-v-erbB)4496Waw Cdkn2atm1Rdp |
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| Release
Category (Required for MTA form):
B
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| Animal Health Report in PDF Format |
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| Strain
Information in Cancer Models Database |
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| Strain
Description: |
On an Ink4a/Arf null background these mice are predisposed to high-grade oligodendroglioma. On an Ink4a/Arf wt background they are predisposed to a low-grade oligodendroglioma. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Cyclin-dependent kinase inhibitor 2A, erythroblastic leukemia viral oncogene homolog
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Gene
Symbol: |
Cdkn2a, v-erbB
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
, s100B |
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Promoter
Symbol: |
, s100B |
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Current
Genetic Background: |
B6.Cg |
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Approx.
Generation: |
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Organ
Site : |
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Cryopreservation Mating Scheme: |
Cdkn2a homozygous females x hemizygous transgenic males |
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| Genotyping Information: |
Protocol 1: Allele: Tg(s100B-v-erbB)4496Waw
Protocol 1: Allele: Cdkn2a
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| Donating
Investigator: |
Dr. William Weiss |
| Key
Reference: |
Weiss WA, Burns MJ, Hackett C, Aldape K, Hill JR, Kuriyama H, Kuriyama N, Milshteyn N, Roberts T, Wendland MF, DePinho R, Israel MA. Genetic determinants of malignancy in a mouse model for oligodendroglioma. Cancer Res. 2003 Apr 1;63(7):1589-95.
PMID: 12670909
[PubMED
Abstract]
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