|
|
|
| Strain Number: | 01XD2 | ||
| Common Strain Name: | TH-MYCN | ||
| Strain Nomenclature: | 129X1/SvJ-Tg(TH-MYCN)41Waw | ||
| Release Category (Required for MTA form): B,D | |||
| Strain Information in Cancer Models Database | |||
| Strain Description: | The rat TH promoter directs expression of the human MYCN transgene to migrating cells of the neural crest during early development. Expression was found in the adrenal gland with marginal expression in brain, heart, testes and spleen. Mice carrying this transgene are predisposed to neuroblastoma and show many of the features of the human childhood disease. Genomic analysis of tumors have shown allelic imbalance in chromosomal regions orthologous to those found in human neuroblastoma. | ||
| Mutation Information | |||
| Mutation Type: | Transgenic | ||
| Gene Name: | |||
| Gene Symbol: | |||
| Transgene Name: | Neuroblastoma myc-related oncogene 1 (human) | ||
| Transgene Symbol: | MYCN | ||
| Promoter Name: | Tyrosine hydroxylase (rat) | ||
| Promoter Symbol: | TH | ||
| Current Genetic Background: | 129X1/SvJ | ||
| Approx. Generation: | |||
| Organ Site : | CNS | ||
| Cryopreservation Mating Scheme: | Wild-type females (129X1/SvJ) x hemizygous males | ||
| Genotyping Information: | Protocol 1: Allele: Tg(TH-MYCN)41Waw | ||
| Donating Investigator: | Dr. William Weiss | ||
| Key Reference: | Weiss WA, Aldape K, Mohapatra G, Feuerstein BG, Bishop JM. 1997 Targeted expression of MYCN causes neuroblastoma in transgenic mice. EMBO J. 16:2985-95. PMID: 9214616 [PubMED Abstract] | ||
| Related References: | Weiss WA, Godfrey T, Francisco C, Bishop JM. 2000 Genome-wide Screen for Allelic Imbalance in a Mouse Model for Neuroblastoma. Cancer Res. 60: 2483-2487. PMID: 10811128 [PubMED Abstract] | ||
 |
 |
 |