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| Strain
Number: |
01XC7 |
| Common
Strain Name: |
Men1 null, Men1deltaN3-8 |
| Strain
Nomenclature: |
FVB;129-Men1tm1.1Ctre |
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| Release
Category (Required for MTA form):
B
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| Animal Health Report in PDF Format |
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| Strain
Description: |
This strain carries a deletion of exons 3-8 in the multiple endocrine neoplasia, type 1 tumor suppressor gene. Mice heterozygous for the Men1tm1Ctre allele develop a phenotype very similar to the human MEN1 disease. By nine months of age pancreatic islets exhibit hyperplasia and insulin-producing islet cell tumors. Parathyroid adenomas are also seen. By sixteen months of age larger pancreatic and parathyroid tumors are found as well as tumors of the thyroid, adrenal cortex and pituitary. These tumors form as a result of loss of heterozygosity (LOH). Mice homozygous for the mutation die in utero at E11.5-12.5. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Multiple endocrine neoplasia 1
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Gene
Symbol: |
Men1
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
129;FVB |
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Approx.
Generation: |
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Organ
Site : |
All |
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Cryopreservation Mating Scheme: |
FVB/N females x heterozygous males |
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| Genotyping Information: |
Protocol 1: Allele: Men1
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| Donating
Investigator: |
Dr. Judy Crabtree |
| Key
Reference: |
Crabtree JS, Scacheri PC, Ward JM, Garrett-Beal L, Emmert-Buck MR, Edgemon KA, Lorang D, Libutti SK, Chandrasekharappa SC, Marx SJ, Spiegel AM, Collins FS. 2001. A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proc Natl Acad Sci USA, 98: 1118-1123.
PMID: 11158604
[PubMED
Abstract]
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