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| Strain Number: | 01XB6 | ||
| Common Strain Name: | Tyr-rtTA | ||
| Strain Nomenclature: | FVB-Tg(Tyr-rtTA)37Lc | ||
| Release Category (Required for MTA form): B,D | |||
| Animal Health Report in PDF Format | |||
| Strain Description: | This strain carries the tetracycline reverse transcriptional activator (rtTA) under the control of the tyrosinase promoter/enhancer (Tyr). The rtTA binds to tetracycline operator elements (TetO) in the presence of doxycycline, causing transcriptional activation of genes downstream of TetO. In normal use this strain would be mated with a transgenic strain carrying a transgene under the control of TetO. | ||
| Mutation Information | |||
| Mutation Type: | Transgenic | ||
| Gene Name: | |||
| Gene Symbol: | |||
| Transgene Name: | Tetracycline reverse transcriptional activator | ||
| Transgene Symbol: | rtTA | ||
| Promoter Name: | tyrosinase promoter/enhancer | ||
| Promoter Symbol: | Tyr | ||
| Current Genetic Background: | FVB/N | ||
| Approx. Generation: | 16 | ||
| Organ Site : | Skin | ||
| Cryopreservation Mating Scheme: | Hemizygous males x wildtype FVB/N females | ||
| Genotyping Information: | Protocol 1: Allele: Tg(Tyr-rtTA)37Lc | ||
| Donating Investigator: | Dr. Lynda Chin | ||
| Key Reference: | Chin L, Tam A, Pomerantz J, Wong M, Holash J, Bardeesy N, Shen Q, O'Hagan R, Pantginis J, Zhou H, Horner JW 2nd, Cordon-Cardo C, Yancopoulos GD, DePinho RA. 1999. Essential role for oncogenic Ras in tumour maintenance. Nature 400:468-72. PMID: 10440378 [PubMED Abstract] | ||
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