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Strain
Number: |
01XB5 |
Common
Strain Name: |
Tyr-HRAS |
Strain
Nomenclature: |
FVB/N-Tg(Tyr-HRAS)60Lc |
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Release
Category (Required for MTA form):
B,D
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Animal Health Report in PDF Format |
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Strain
Information in Cancer Models Database |
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Strain
Description: |
This strain carries an activated human HRAS gene (G12V) that is expressed in melanocytes. The transgene integrated on the mouse Y chromosome and therefore, only males develop tumors. On an Ink4a/Arf null background, spontaneous cutaneous tumors develop most commonly in the pinna of the ear, torso, tail, and perineum area. Ocular tumors are seen occasionally. Tumors are locally invasive with no evidence of metastasis. On a wild-type Ink4a/Arf background, there is a very low tumor frequency after a long latency. |
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Mutation
Information |
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Mutation
Type: |
Transgenic |
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Gene
Name: |
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Gene
Symbol: |
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Transgene
Name: |
RAS oncogene
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Transgene
Symbol: |
HRAS
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Promoter
Name: |
Tyrosinase enhancer/promoter element |
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Promoter
Symbol: |
Tyr |
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Current
Genetic Background: |
FVB/N |
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Approx.
Generation: |
14 |
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Organ
Site : |
Skin |
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Cryopreservation Mating Scheme: |
FVB/N females x hemizygous males |
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Genotyping Information: |
Protocol 1: Allele: Tg(Tyr-HRAS)60Lc
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Donating
Investigator: |
Dr. Lynda Chin |
Key
Reference: |
Lynda Chin, Jason Pomerantz, David Polsky, Mark Jacobson, Carlos Cohen, Carlos Cordon-Cardo, James W. Horner, II, and Ronald A. DePinho. 1997. Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. Genes Dev. 11: 2822-2834.
PMID: 9353252
[PubMED
Abstract]
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