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| Strain
Number: |
01XAA |
| Common
Strain Name: |
Apc CKO |
| Strain
Nomenclature: |
B6.Cg-Apctm2Rak |
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| Release
Category (Required for MTA form):
B,D
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| Animal Health Report in PDF Format |
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| Strain
Description: |
This strain carries a conditional allele of Apc with two LoxP sites flanking exon14 (a FRT-flanked neomycin resistance cassette was removed by FLP-mediated recombination). Homozygous mice are phenotypically normal and fertile. These animals can be used for tissue-specific ablation of Apc function. Deletion of exon 14 by cre-mediated recombination leads to expression of a truncated Apc protein of 605 amino acid residues (aa), of which the first 580 aa correspond to the normal protein. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Adenomatosis polyposis coli
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Gene
Symbol: |
Apc
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
B6.Cg |
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Approx.
Generation: |
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Organ
Site : |
various |
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Husbandry: |
Homozygote breeder pairs are provided. Average litter size is 7. |
| Genotyping Information: |
Protocol 1: Allele: Apc
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| Donating
Investigator: |
Dr. Raju Kucherlapati |
| Key
Reference: |
Kuraguchi M, Wang XP, Bronson RT, Rothenberg R, Ohene-Baah NY, Lund JJ, Kucherlapati M, Maas RL, Kucherlapati R. Adenomatous polyposis coli (Apc) is required for normal development of skin and thymus. PLoS Genetics 2, 1362-1374, 2006. PMID 17002498
[PubMED
Abstract]
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