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| Strain
Number: |
01BM1 |
| Common
Strain Name: |
Bloom homolog mutant |
| Strain
Nomenclature: |
B6;129S-Blmtm3Brd |
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| Release
Category (Required for MTA form):
B,D
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| Animal Health Report in PDF Format |
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| Strain
Information in Cancer Models Database |
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| Strain
Description: |
Increased mitotic recombination occurs in cells from Blm-deficient mice, leading to increased rates of LOH (loss of heterozygosity). Meiotic recombination is normal. A variety of malignant and benign tumors develop in Blm-deficient mice, usually after one year of age. The tumor spectrum includes lymphomas, sarcomas and carcinomas. This strain provides a model for Bloom syndrome in humans as well as a model to study genomic instability. In addition the increased rate of LOH coupled with the late tumor onset make this strain valuable in identifying recessive cancer mutations through somatic genetics. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Bloom syndrome homolog
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Gene
Symbol: |
Blm
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
B6;129S2 |
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Approx.
Generation: |
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Organ
Site : |
All |
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Husbandry: |
Homozygous breeder pairs are provided. |
| Genotyping Information: |
Protocol 1: Allele: Blm
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| Donating
Investigator: |
Dr. Alan Bradley |
| Key
Reference: |
Luo G, Santoro IM, McDaniel LD, Nishijima I, Mills M, Youssoufian H, Vogel H, Schultz RA, Bradley A.Cancer predisposition caused by elevated mitotic recombination in Bloom mice. 2000 Nat Genet 26:424-9.
PMID: 11101838
[PubMED
Abstract]
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