Strain
Code: |
01XAE |
Common
Strain Name: |
WAP-Tag |
Strain
Nomenclature: |
B6.Cg-Tg(WapTag)8Gmn |
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Strain
Description: |
These mice express SV40 T/t antigen under control of the lactotropic hormone-inducible whey acidic protein (Wap) promoter, which is specific for mammary gland epithelial (ME) cells. Females synthesize T/t antigen (Tag) in ME cells during pregnancy and the lactation period. Mice that undergo at least one pregnancy develop palpable mammary tumors (adenocarcinomas) at 6 months of age. Female transgenic mice cannot be used as breeders due to a lactation defect. |
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Mutation
Information |
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Mutation
Type: |
Transgenic |
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Gene
Name: |
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Gene
Symbol: |
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Transgene
Name: |
SV40 Large T antigen
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Transgene
Symbol: |
TAg
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Promoter
Name: |
Wap (mouse) |
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Promoter
Symbol: |
Wap |
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Current
Genetic Background: |
B6.Cg |
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Approx.
Generation: |
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Organ
Site : |
Mammary gland |
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Donating
Investigator: |
Dr. Esta Sterneck |
Reference: |
Tzeng YJ, Guhl E, Graessmann M, Graessmann A. Breast cancer formation in transgenic animals induced by the whey acidic protein SV40 T antigen (WAP-SV-T) hybrid gene. Oncogene 8, 1965-1971, 1993. PMID 8390039 |
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PubMED
Abstract |
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