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| Strain Code: | 01XAE | ||
| Common Strain Name: | WAP-Tag | ||
| Strain Nomenclature: | B6.Cg-Tg(WapTag)8Gmn | ||
| Strain Description: | These mice express SV40 T/t antigen under control of the lactotropic hormone-inducible whey acidic protein (Wap) promoter, which is specific for mammary gland epithelial (ME) cells. Females synthesize T/t antigen (Tag) in ME cells during pregnancy and the lactation period. Mice that undergo at least one pregnancy develop palpable mammary tumors (adenocarcinomas) at 6 months of age. Female transgenic mice cannot be used as breeders due to a lactation defect. | ||
| Mutation Information | |||
| Mutation Type: | Transgenic | ||
| Gene Name: | |||
| Gene Symbol: | |||
| Transgene Name: | SV40 Large T antigen | ||
| Transgene Symbol: | TAg | ||
| Promoter Name: | Wap (mouse) | ||
| Promoter Symbol: | Wap | ||
| Current Genetic Background: | B6.Cg | ||
| Approx. Generation: | |||
| Organ Site : | Mammary gland | ||
| Donating Investigator: | Dr. Esta Sterneck | ||
| Reference: | Tzeng YJ, Guhl E, Graessmann M, Graessmann A. Breast cancer formation in transgenic animals induced by the whey acidic protein SV40 T antigen (WAP-SV-T) hybrid gene. Oncogene 8, 1965-1971, 1993. PMID 8390039 | ||
| PubMED Abstract | |||
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