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Biometry Research Group

Curriculum Vitae for Grant Izmirlian, Ph.D.

Mathematical Statistician

US Mail Address
Biometry Research Group, DCP
National Cancer Institute
Executive Plaza North, Room 3131
6130 Executive Blvd, MSC 7354
Bethesda, MD 20892-7354
Shipping Address
Biometry Research Group, DCP
National Cancer Institute
6130 Executive Blvd, Room 3131
Rockville, MD 20852
Phone: 301.496.7519 Fax: 301.402.0816
E-mail: Izmirlian@nih.gov


Professional Experience

08/1999-presentMathematical Statistician
Biometry Research Group, Division of Cancer Prevention
National Cancer Institute, National Institutes of Health
Bethesda, MD
02/1998-08/1999Senior Staff Fellow
Biometry Office, Epidemiology Demography & Biometry Program
National Institute on Aging
Bethesda, MD
06/1993-08/1993Actuarial Research Intern
Corporate Actuarial Department
The Principal Financial Group; Des Moines, Iowa.
09/1992-05/1993Visiting Assistant Professor
Department of Mathematics and Computer Science
Drake University, Des Moines, Iowa
09/1992-05/1993Teaching Assistant
Department of Mathematics
University of Wisconsin-Madison
06/1996-08/1996Graduate Research Fellow
General Motors Technical Center, Warren, Michigan
Department of Mathematics and Statistics

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Education

08/1996-02/1998IRTA Fellowship
Epidemiology, Demography, and Biometry Program
National Institute on Aging, Bethesda, Maryland
08/1994-08/1996Post-doctoral Training Fellowship in the
Carolina Population Center and Biostatistics Department
University of North Carolina–Chapel Hill
05/1993PhD in Mathematics (Probability Theory)
with a minor in Computer Science
University of Wisconsin–Madison
Thesis: Large deviations for additive functionals of a Markov exchangeable sequence.
Advisor: Peter E. Ney, Professor of Mathematics
05/1984BA in Mathematics and Chemistry
Drake University
Des Moines, Iowa

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Awards and Honors

2002Distinguished Service Award
National Cancer Institute; Bethesda, Maryland
1999Performance Award
National Institute on Aging; Bethesda, Maryland
1998Fellows Award for Research Excellence
National Institutes of Health
1994Carolina Population Center Fellowship
University of North Carolina-Chapel Hill
1992Department of Education Fellowship
Department of Mathematics
University of Wisconsin-Madison
1984Member, Phi Beta Kappa
1984Graduated summa cum laude
Drake University; Des Moines, Iowa
1982 & 1983Summer Landau Fellow in Physical Chemistry
University of Minnesota-Minneaplolis

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Memberships

  • American Statistical Association
  • Eastern North American Region of the International Biometric Society
  • Institute of Mathematical Statistics
  • Interface Society of North America

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Referee Services

  • Journal of Computational and Graphical Statistics
  • Journal of Mathematical Population Studies
  • Statistics in Medicine

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Editorial Boards

  • Cancer Informatics

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Research Interests

  1. Statistical analysis of proteomics, SNP and microarray data
  2. Statistical issues related to interim analysis
  3. Stochastic processes issues in natural history models for cancer screening trials

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Bibliography

Peer-Reviewed Journals

Izmirlian G. Response to 'Receiver operating characteristics of the prostate-specific antigen test in an unselected population'. J Med Screen 2006;13(4):214; author reply 215.

Steele VE, Arnold JT, Le H, Izmirlian G, Blackman MR. Comparative effects of DHEA and DHT on gene expression in human LNCaP prostate cancer cells. Anticancer Research 2006;26:3205-3216.

Xu J-L, Izmirlian G. Estimation of location parameters for a spherically symmetric distribution. Journal of Multivariate Analysis 2006;97:514-525.

Andriole GL, Levin DL, Crawford ED, Gelmann EP, Pinsky PF, Chia D, Kramer BS, Reding D, Church TR, Grubb RL, Izmirlian G, Ragard LR, Clapp JD, Prorok PC, Gohagan JK, for the PLCO Project Team. Prostate cancer screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial: findings from the initial screening round of a randomized trial. J Natl Cancer Inst 2005;97:433-438.

Baker SG,Izmirlian G, Kipnis V. Resolving paradoxes involving surrogate endpoints (pdf, 114kb). J R Statist Soc A 2005;168(4):753-762.

Buys SS, Partridge E, Greene MH, Prorok PC, Reding D, Riley TL, Hartge P, Fagerstrom RM, Ragard LR, Chia D, Izmirlian G, Fouad M, Johnson CC, Gohagan JK, for the PLCO Project Team. Ovarian cancer screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial: findings from the initial screen of a randomized trial. Am J Obstet Gynecol 2005;193(5):1630-1639.

Cronin KA, Yu B, Krapcho M, Miglioretti DL, Fay MP,Izmirlian G, BallardBarbash R, Geller BM, Feuer EJ. Modeling the dissemination of mammography in the United States. Cancer Causes Control 2005;16(6):701-712.

Izmirlian G. Application of the random forest classification algorithm to a SELDITOF proteomics study in the setting of a cancer prevention trial. Ann NY Acad Sci 2004;1020:154-174.

Kapetanovic IM, Rosenfeld S, Izmirlian G. Overview of commonly used bioinformatics methods and their applications. Ann NY Acad Sci 2004;1020:10-21.

Xiao Z, Luke BT, Izmirlian G, Umar A, Lynch PM, Phillips RK, Patterson S, Conrads TP, Veenstra TD, Greenwald P, Hawk ET, Ali IU. Serum proteomic profiles suggest celecoxib-modulated targets and response predictors. Cancer Res 2004;64(8):2904-2909.

Melzer D, Izmirlian G, Leveille SG, Guralnik JM. Educational differences in the prevalence of mobility disability in old age: the dynamics of incidence, mortality, and recovery.J Gerontol B Psychol Sci Soc Sci 2001;56(5):S294-301.

Havlik RJ, Izmirlian G, Petrovitch H, Ross GW, Masaki K, Curb JD, Saunders AM, Foley DJ, Brock D, Launer LJ, White L. APOE-epsilon4 predicts incident AD in Japanese-American men: the Honolulu-Asia Aging Study. Neurology 2000;54(7):1526-1529.

Izmirlian G, Brock D, Ferrucci L, Phillips C. Active life expectancy from annual follow-up data with missing responses. Biometrics 2000;56(1):244-248.

Izmirlian G, Brock D, White L. Estimating incidence of dementia subtypes: assessing the impact of missed cases. Stat Med 2000;19(11-12):1577-1591

Leveille SG, Penninx BW, Melzer D, Izmirlian G, Guralnik JM. Sex differences in the prevalence of mobility disability in old age: the dynamics of incidence, recovery and mortality. J Gerontol B Psychol Sci Soc Sci 2000;55(1):S41-50.

Masaki KH, Losonczy KG, Izmirlian G, Foley DJ, Ross GW, Petrovitch H, Havlik R, White LR. Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology 2000;54(6):1265-1272.

Masaki KH, White LR, Foley DJ, Petrovitch H, Izmirlian G, Havlik R, Ross GW, Losonczy KG. Association of vitamin E and C supplement use with cognitive function and dementia in elderly men - Reply.Neurology 2000;55(6):901-902.

Petrovitch H, White LR,Izmirlian G, Ross GW, Havlik RJ, Markesbery W, Nelson J, Davis DG, Hardman J, Foley DJ, Launer LJ. Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS. Neurobiology of Aging 2000;21:57-62.

Corti MC, Guralnik JM, Ferrucci L, Izmirlian G, Leveille SG, Pahor M, Cohen HJ, Pieper C, Havlik RJ. Evidence for a black-white crossover in all-cause and coronary heart disease mortality in an older population: the North Carolina EPESE. Am J Public Health 1999;89(3):308-314.

Ferrucci L,Izmirlian G, Leveille S, Phillips CL, Corti MC, Brock DB, Guralnik JM. Smoking, physical activity, and active life expectancy. Am J Epidemiol 1999;149(7):645-653.

Foley DJ, Monjan AA,Izmirlian G, Hays JC, Blazer DG. Incidence and remission of insomnia among elderly adults in a biracial cohort. Sleep 1999;22 Suppl 2:S373-378.

Rantanen T, Guralnick JM, Izmirlian G, Williamson JD, Simonsick EM, Ferrucci L, Fried LP. Association of muscle strength with maximum walking speed in disabled older women. Am J Phys Med Rehabil 1998;77(4):299-305.

Rantanen T, Guralnick JM, Leveille S, Izmirlian G, Hirsch R, Simonsick E, Ling S, Fried LP. Racial differences in muscle strength in disabled older women. J Gerontol A Biol Sci Med Sci 1998;53(5):B355-361.

Rantanen T, Masaki K, Foley D, Izmirlian G, White L, Guralnik JM. Grip strength changes over 27 yr in Japanese-American men. J Appl Physiol 1998;85(6):2047-2053.

Izmirlian G, Adewuyi AA, Suchindran CM. Analysis of contraceptive discontinuation in six developing countries from durations of use at survey. Soc Biol 1997;44(1-2):124-135.

Thompson TC, Izmirlian G, Lemon S, Truhlar DG, Mead CA. Consistent analytic representation of the two lowest potential energy surfaces for Li3, Na3, and K3. Journal of Chemical Physics 1985;82(12):5597-5603.

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Published Abstracts

Tooze JA,Izmirlian G, Brown C, Perkins S, Hursting S. Armitage-Doll analysis of diet : p53 gene dosage interactions in p53-deficient and wild-type mice.FASEB J 2003(Mar 17);17(5 Part 2 Suppl S):A1153.

Wang T, Izmirlian G, Takahashi Y, Perkins S, Hursting S. Microarray expression profiling of LNCaP prostate cancer cell gene expression following exposure to the soy isoflavone genistein. FASEB J 2003(Mar 17):17(5 Part 2 Suppl S):A1372.

Kipnis V,Izmirlian G. The impact of categorization of continuous exposure measured with error. Am J Epidemiol 2002(June 1):155(11):S28 (Abstract 111).

Kipnis V, Izmirlian G, Midthune D, Subar A, Schatzkin A. Misclassification of dietary exposure and its implications: results from the Observing Protein and Energy Nutrition (OPEN) Biomarker Study. Am J Epidemiol 2002(June 1):155(11):S28 (Abstract 110).

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This page was last updated April 23, 2007.