Projects and Investigators

FY 2004 Projects

University of Wisconsin-Madison

Objective

Polyamine analog SL11217 for prevention of colon and duodenal neoplasia.

Program Description

Experimental evidence suggests that regulating polyamine metabolism may be useful in the prevention and treatment of colon cancer. Polyamine analogs and polyamine synthesis inhibitors have shown chemopreventive activities. SL-11217, a novel porphyrin polyamine conjugate, yielded encouraging preliminary results. It combines the antiproliferative effects of polyamine analogs with tumor-targeting potential of porphyrins which are expected to maximize efficacy and minimize systemic toxicity. The initial RAPID support may include:

• Scale up GMP synthesis and
• Preclinical pharmacology and toxicology studies.

Contact Information

Dr. Russell F. Jacoby
University of Wisconsin-Madison
Madison, WI
Tel: 608-256-1901
Fax: 608-280-7292
E-mail: rfjacoby@wisc.edu