Projects and Investigators

FY 2001 Projects

American Health Foundation

Objective

Preclinical development of sulforaphane, a major constituent in broccoli.

Program Description

Investigators will conduct preclinical development of sulforaphane, a major constituent in broccoli. The consumption of cruciferous vegetables is associated with a reduced risk of cancer at various organ sites. Isothiocyanates are abundantly present in these vegetables and are thought to be major contributors to their chemopreventive activities. Sulforaphane is a major isothiocyanate in broccoli and has shown chemopreventive activity in various animal models. RAPID support will include:

• Synthesis of bulk and 14C-labeled material for preclinical studies,
• Mutagenicity and short term preclinical toxicity testing,
• Preclinical absorption, distribution, metabolism, elimination and pharmacokinetic studies,
• In vivo screening and efficacy studies, and
• Formulation.

Contact Information

Fung-Lung Chung, Ph.D.
Presently
Professor
Department of Oncology
Lombardi Comprehensive Cancer Center
Georgetown University Medical Center
3800 Reservoir Rd. NW LL(S) level
Rm 128, Box 571465
Washington, DC 20057-1465
Tel: 202-687-3021
E-mail: flc6@georgetown.edu